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Four Genetic Polymorphisms of Lymphotoxin-Alpha Gene and Cancer Risk: A Systematic Review and Meta-Analysis

Author

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  • Yi Huang
  • Xi Yu
  • Lingyan Wang
  • Shengjun Zhou
  • Jie Sun
  • Nan Feng
  • Sheng Nie
  • Jingmi Wu
  • Feng Gao
  • Bing Fei
  • Jianyong Wang
  • Zhiqing Lin
  • Xianru Li
  • Leiting Xu
  • Xiang Gao
  • Meng Ye
  • Shiwei Duan

Abstract

Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine that plays an important role in the inflammatory and immunologic response. Numerous studies have shown LTA polymorphisms as risk factors for cancers, but the results remain inconclusive. The goal of the present meta-analyses is to establish the associations between cancers and four LTA variants (rs1041981, rs2239704, rs2229094 and rs746868). A total of 30 case-control studies involving 58,649 participants were included in the current meta-analyses. Our results showed significant associations with increased cancer risk for rs1041981 (odd ratio (OR) = 1.15, 99% confidential interval (CI) = 1.07-1.25, P

Suggested Citation

  • Yi Huang & Xi Yu & Lingyan Wang & Shengjun Zhou & Jie Sun & Nan Feng & Sheng Nie & Jingmi Wu & Feng Gao & Bing Fei & Jianyong Wang & Zhiqing Lin & Xianru Li & Leiting Xu & Xiang Gao & Meng Ye & Shiwei, 2013. "Four Genetic Polymorphisms of Lymphotoxin-Alpha Gene and Cancer Risk: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    • Handle: RePEc:plo:pone00:0082519
    DOI: 10.1371/journal.pone.0082519
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    References listed on IDEAS

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    1. Lisa M. Coussens & Zena Werb, 2002. "Inflammation and cancer," Nature, Nature, vol. 420(6917), pages 860-867, December.
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