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Native Gating Behavior of Ion Channels in Neurons with Null-Deviation Modeling

Author

Listed:
  • Wei Wang
  • Jie Luo
  • Panpan Hou
  • Yimei Yang
  • Feng Xiao
  • Ming Yuchi
  • Anlian Qu
  • Luyang Wang
  • Jiuping Ding

Abstract

Computational modeling has emerged as an indispensable approach to resolve and predict the intricate interplay among the many ion channels underlying neuronal excitability. However, simulation results using the classic formula-based Hodgkin-Huxley (H-H) model or the superior Markov kinetic model of ion channels often deviate significantly from native cellular signals despite using carefully measured parameters. Here we found that the filters of patch-clamp amplifier not only delayed the signals, but also introduced ringing, and that the residual series resistance in experiments altered the command voltages, which had never been fully eliminated by improving the amplifier itself. To remove all the above errors, a virtual device with the parameters exactly same to that of amplifier was introduced into Markov kinetic modeling so as to establish a null-deviation model. We demonstrate that our novel null-deviation approach fully restores the native gating-kinetics of ion-channels with the data recorded at any condition, and predicts spike waveform and firing patterns clearly distinctive from those without correction.

Suggested Citation

  • Wei Wang & Jie Luo & Panpan Hou & Yimei Yang & Feng Xiao & Ming Yuchi & Anlian Qu & Luyang Wang & Jiuping Ding, 2013. "Native Gating Behavior of Ion Channels in Neurons with Null-Deviation Modeling," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-10, October.
  • Handle: RePEc:plo:pone00:0077105
    DOI: 10.1371/journal.pone.0077105
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    References listed on IDEAS

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    1. Wei Wang & Feng Xiao & Xuhui Zeng & Jing Yao & Ming Yuchi & Jiuping Ding, 2012. "Optimal Estimation of Ion-Channel Kinetics from Macroscopic Currents," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-12, April.
    2. Meron Gurkiewicz & Alon Korngreen, 2007. "A Numerical Approach to Ion Channel Modelling Using Whole-Cell Voltage-Clamp Recordings and a Genetic Algorithm," PLOS Computational Biology, Public Library of Science, vol. 3(8), pages 1-15, August.
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