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Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants

Author

Listed:
  • Daniel J Smith
  • Barbara I Nicholl
  • Breda Cullen
  • Daniel Martin
  • Zia Ul-Haq
  • Jonathan Evans
  • Jason M R Gill
  • Beverly Roberts
  • John Gallacher
  • Daniel Mackay
  • Matthew Hotopf
  • Ian Deary
  • Nick Craddock
  • Jill P Pell

Abstract

Objectives: UK Biobank is a landmark cohort of over 500,000 participants which will be used to investigate genetic and non-genetic risk factors for a wide range of adverse health outcomes. This is the first study to systematically assess the prevalence and validity of proposed criteria for probable mood disorders within the cohort (major depression and bipolar disorder). Methods: This was a descriptive epidemiological study of 172,751 individuals assessed for a lifetime history of mood disorder in relation to a range of demographic, social, lifestyle, personality and health-related factors. The main outcomes were prevalence of a probable lifetime (single) episode of major depression, probable recurrent major depressive disorder (moderate), probable recurrent major depressive disorder (severe), probable bipolar disorder and no history of mood disorder (comparison group). Outcomes were compared on age, gender, ethnicity, socioeconomic status, educational attainment, functioning, self-reported health status, current depressive symptoms, neuroticism score, smoking status and alcohol use. Results: Prevalence rates for probable single lifetime episode of major depression (6.4%), probable recurrent major depression (moderate) (12.2%), probable recurrent major depression (severe) (7.2%) and probable bipolar disorder (1.3%) were comparable to those found in other population studies. The proposed diagnostic criteria have promising validity, with a gradient in evidence from no mood disorder through major depression and probable bipolar disorder in terms of gender distribution, socioeconomic status, self-reported health rating, current depressive symptoms and smoking. Significance: The validity of our proposed criteria for probable major depression and probable bipolar disorder within this cohort are supported by these cross-sectional analyses. Our findings are likely to prove useful as a framework for a wide range of future genetic and non-genetic studies.

Suggested Citation

  • Daniel J Smith & Barbara I Nicholl & Breda Cullen & Daniel Martin & Zia Ul-Haq & Jonathan Evans & Jason M R Gill & Beverly Roberts & John Gallacher & Daniel Mackay & Matthew Hotopf & Ian Deary & Nick , 2013. "Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0075362
    DOI: 10.1371/journal.pone.0075362
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    Cited by:

    1. Donald M Lyall & Breda Cullen & Mike Allerhand & Daniel J Smith & Daniel Mackay & Jonathan Evans & Jana Anderson & Chloe Fawns-Ritchie & Andrew M McIntosh & Ian J Deary & Jill P Pell, 2016. "Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-10, April.
    2. Andras Gezsi & Sandra Auwera & Hannu Mäkinen & Nora Eszlari & Gabor Hullam & Tamas Nagy & Sarah Bonk & Rubèn González-Colom & Xenia Gonda & Linda Garvert & Teemu Paajanen & Zsofia Gal & Kevin Kirchner, 2024. "Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Jonsdottir, Gudrun A. & Einarsson, Gudmundur & Thorleifsson, Gudmar & Magnusson, Sigurdur H. & Gunnarsson, Arni F. & Frigge, Michael L. & Gisladottir, Rosa S. & Unnsteinsdottir, Unnur & Gunnarsson, Bj, 2021. "Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophrenia," Intelligence, Elsevier, vol. 88(C).
    4. Aleksandr Talishinsky & Jonathan Downar & Petra E. Vértes & Jakob Seidlitz & Katharine Dunlop & Charles J. Lynch & Heather Whalley & Andrew McIntosh & Fidel Vila-Rodriguez & Zafiris J. Daskalakis & Da, 2022. "Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    5. Avendano, Mauricio & de Coulon, Augustin & Nafilyan, Vahé, 2020. "Does longer compulsory schooling affect mental health? Evidence from a British reform," Journal of Public Economics, Elsevier, vol. 183(C).

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