IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0074855.html
   My bibliography  Save this article

High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers

Author

Listed:
  • Olivier Lambotte
  • Justin Pollara
  • Faroudy Boufassa
  • Christiane Moog
  • Alain Venet
  • Barton F Haynes
  • Jean-François Delfraissy
  • Asier Saez-Cirion
  • Guido Ferrari

Abstract

The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.

Suggested Citation

  • Olivier Lambotte & Justin Pollara & Faroudy Boufassa & Christiane Moog & Alain Venet & Barton F Haynes & Jean-François Delfraissy & Asier Saez-Cirion & Guido Ferrari, 2013. "High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-5, September.
    • Handle: RePEc:plo:pone00:0074855
    DOI: 10.1371/journal.pone.0074855
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074855
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074855&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0074855?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ann J. Hessell & Lars Hangartner & Meredith Hunter & Carin E. G. Havenith & Frank J. Beurskens & Joost M. Bakker & Caroline M. S. Lanigan & Gary Landucci & Donald N. Forthal & Paul W. H. I. Parren & P, 2007. "Fc receptor but not complement binding is important in antibody protection against HIV," Nature, Nature, vol. 449(7158), pages 101-104, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Luis M. Molinos-Albert & Valérie Lorin & Valérie Monceaux & Sylvie Orr & Asma Essat & Jérémy Dufloo & Olivier Schwartz & Christine Rouzioux & Laurence Meyer & Laurent Hocqueloux & Asier Sáez-Cirión & , 2022. "Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Karunasinee Suphaphiphat & Delphine Desjardins & Valérie Lorin & Nastasia Dimant & Kawthar Bouchemal & Laetitia Bossevot & Maxence Galpin-Lebreau & Nathalie Dereuddre-Bosquet & Hugo Mouquet & Roger Gr, 2023. "Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. David A. Spencer & Benjamin S. Goldberg & Shilpi Pandey & Tracy Ordonez & Jérémy Dufloo & Philip Barnette & William F. Sutton & Heidi Henderson & Rebecca Agnor & Lina Gao & Timothée Bruel & Olivier Sc, 2022. "Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Joana Dias & Giulia Fabozzi & Slim Fourati & Xuejun Chen & Cuiping Liu & David R. Ambrozak & Amy Ransier & Farida Laboune & Jianfei Hu & Wei Shi & Kylie March & Anna A. Maximova & Stephen D. Schmidt &, 2024. "Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Lucia Reh & Carsten Magnus & Merle Schanz & Jacqueline Weber & Therese Uhr & Peter Rusert & Alexandra Trkola, 2015. "Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent," PLOS Pathogens, Public Library of Science, vol. 11(7), pages 1-34, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0074855. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.