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Genome Wide Association Study of Age at Menarche in the Japanese Population

Author

Listed:
  • Chizu Tanikawa
  • Yukinori Okada
  • Atsushi Takahashi
  • Katsutoshi Oda
  • Naoyuki Kamatani
  • Michiaki Kubo
  • Yusuke Nakamura
  • Koichi Matsuda

Abstract

Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identify the genetic factors associated with AAM, we conducted a large-scale meta-analysis of genome-wide association studies using more than 15,000 Japanese female samples. Here, we identified an association between SNP (single nucleotide polymorphism) rs364663 at the LIN28B locus and AAM, with a P-value of 5.49×10−7 and an effect size of 0.089 (year). We also evaluated 33 SNPs that were previously reported to be associated with AAM in women of European ancestry. Among them, two SNPs rs4452860 and rs7028916 in TMEM38B indicated significant association with AAM in the same directions as reported in previous studies (P = 0.0013 with an effect size of 0.051) even after Bonferroni correction for the 33 SNPs. In addition, six loci in or near CCDC85A, LOC100421670, CA10, ZNF483, ARNTL, and RXRG exhibited suggestive association with AAM (P

Suggested Citation

  • Chizu Tanikawa & Yukinori Okada & Atsushi Takahashi & Katsutoshi Oda & Naoyuki Kamatani & Michiaki Kubo & Yusuke Nakamura & Koichi Matsuda, 2013. "Genome Wide Association Study of Age at Menarche in the Japanese Population," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-8, May.
    • Handle: RePEc:plo:pone00:0063821
    DOI: 10.1371/journal.pone.0063821
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    References listed on IDEAS

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    1. Jian Li & Yan-fang Guo & Yufang Pei & Hong-Wen Deng, 2012. "The Impact of Imputation on Meta-Analysis of Genome-Wide Association Studies," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    2. Masayuki Yazawa & Christopher Ferrante & Jue Feng & Kazuhiro Mio & Toshihiko Ogura & Miao Zhang & Pei-Hui Lin & Zui Pan & Shinji Komazaki & Kazuhiro Kato & Miyuki Nishi & Xiaoli Zhao & Noah Weisleder , 2007. "TRIC channels are essential for Ca2+ handling in intracellular stores," Nature, Nature, vol. 448(7149), pages 78-82, July.
    3. Yuji Urabe & Chizu Tanikawa & Atsushi Takahashi & Yukinori Okada & Takashi Morizono & Tatsuhiko Tsunoda & Naoyuki Kamatani & Kenjiro Kohri & Kazuaki Chayama & Michiaki Kubo & Yusuke Nakamura & Koichi , 2012. "A Genome-Wide Association Study of Nephrolithiasis in the Japanese Population Identifies Novel Susceptible Loci at 5q35.3, 7p14.3, and 13q14.1," PLOS Genetics, Public Library of Science, vol. 8(3), pages 1-7, March.
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    Cited by:

    1. Lindsay Fernández-Rhodes & Jennifer R Malinowski & Yujie Wang & Ran Tao & Nathan Pankratz & Janina M Jeff & Sachiko Yoneyama & Cara L Carty & V Wendy Setiawan & Loic Le Marchand & Christopher Haiman &, 2018. "The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic ," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-21, July.

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