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TRIC channels are essential for Ca2+ handling in intracellular stores

Author

Listed:
  • Masayuki Yazawa

    (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    Graduate School of Medicine, Tohoku University, Miyagi 980-8575, Japan)

  • Christopher Ferrante

    (Robert Wood Johnson Medical School, New Jersey 08854, USA)

  • Jue Feng

    (Graduate School of Medicine, Tohoku University, Miyagi 980-8575, Japan)

  • Kazuhiro Mio

    (Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki 305-8568, Japan)

  • Toshihiko Ogura

    (Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki 305-8568, Japan
    PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Miao Zhang

    (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    Graduate School of Medicine, Tohoku University, Miyagi 980-8575, Japan)

  • Pei-Hui Lin

    (Robert Wood Johnson Medical School, New Jersey 08854, USA)

  • Zui Pan

    (Robert Wood Johnson Medical School, New Jersey 08854, USA)

  • Shinji Komazaki

    (Saitama Medical University, Saitama 350-0495, Japan)

  • Kazuhiro Kato

    (Graduate School of Medicine, Tohoku University, Miyagi 980-8575, Japan)

  • Miyuki Nishi

    (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    Graduate School of Medicine, Tohoku University, Miyagi 980-8575, Japan)

  • Xiaoli Zhao

    (Robert Wood Johnson Medical School, New Jersey 08854, USA)

  • Noah Weisleder

    (Robert Wood Johnson Medical School, New Jersey 08854, USA)

  • Chikara Sato

    (Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki 305-8568, Japan)

  • Jianjie Ma

    (Robert Wood Johnson Medical School, New Jersey 08854, USA)

  • Hiroshi Takeshima

    (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    Graduate School of Medicine, Tohoku University, Miyagi 980-8575, Japan)

Abstract

Cell signalling requires efficient Ca2+ mobilization from intracellular stores through Ca2+ release channels, and it has been hypothesized that counter movement of ions across the sarcoplasmic reticulum neutralizes the transient negative potential generated by Ca2+ release. This paper identifies two trimeric intracellular cation channel subtypes that that could serve a critical role in such charge compensation.

Suggested Citation

  • Masayuki Yazawa & Christopher Ferrante & Jue Feng & Kazuhiro Mio & Toshihiko Ogura & Miao Zhang & Pei-Hui Lin & Zui Pan & Shinji Komazaki & Kazuhiro Kato & Miyuki Nishi & Xiaoli Zhao & Noah Weisleder , 2007. "TRIC channels are essential for Ca2+ handling in intracellular stores," Nature, Nature, vol. 448(7149), pages 78-82, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7149:d:10.1038_nature05928
    DOI: 10.1038/nature05928
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    Cited by:

    1. Chizu Tanikawa & Yukinori Okada & Atsushi Takahashi & Katsutoshi Oda & Naoyuki Kamatani & Michiaki Kubo & Yusuke Nakamura & Koichi Matsuda, 2013. "Genome Wide Association Study of Age at Menarche in the Japanese Population," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-8, May.

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