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A Prospective Study of LINE-1DNA Methylation and Development of Adiposity in School-Age Children

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  • Wei Perng
  • Mercedes Mora-Plazas
  • Constanza Marín
  • Laura S Rozek
  • Ana Baylin
  • Eduardo Villamor

Abstract

Background: Repetitive element DNA methylation is related to prominent obesity-related chronic diseases including cancer and cardiovascular disease; yet, little is known of its relation with weight status. We examined associations of LINE-1 DNA methylation with changes in adiposity and linear growth in a longitudinal study of school-age children from Bogotá, Colombia. Methods: We quantified methylation of LINE-1 elements from peripheral leukocytes of 553 children aged 5–12 years at baseline using pyrosequencing technology. Anthropometric characteristics were measured periodically for a median of 30 months. We estimated mean change in three age-and sex-standardized indicators of adiposity: body mass index (BMI)-for-age Z-score, waist circumference Z-score, and subscapular-to-triceps skinfold thickness ratio Z-score according to quartiles of LINE-1 methylation using mixed effects regression models. We also examined associations with height-for-age Z-score. Results: There were non-linear, inverse relations of LINE-1 methylation with BMI-for-age Z-score and the skinfold thickness ratio Z-score. After adjustment for baseline age and socioeconomic status, boys in the lowest quartile of LINE-1 methylation experienced annual gains in BMI-for-age Z-score and skinfold thickness ratio Z-score that were 0.06 Z/year (P = 0.04) and 0.07 Z/year (P = 0.03), respectively, higher than those in the upper three quartiles. The relation of LINE-1 methylation and annual change in waist circumference followed a decreasing monotonic trend across the four quartiles (P trend = 0.02). DNA methylation was not related to any of the adiposity indicators in girls. There were no associations between LINE-1 methylation and linear growth in either sex. Conclusions: Lower LINE-1 DNA methylation is related to development of adiposity in boys.

Suggested Citation

  • Wei Perng & Mercedes Mora-Plazas & Constanza Marín & Laura S Rozek & Ana Baylin & Eduardo Villamor, 2013. "A Prospective Study of LINE-1DNA Methylation and Development of Adiposity in School-Age Children," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0062587
    DOI: 10.1371/journal.pone.0062587
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    References listed on IDEAS

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    1. Howard H Yang & Nan Hu & Chaoyu Wang & Ti Ding & Barbara K Dunn & Alisa M Goldstein & Philip R Taylor & Maxwell P Lee, 2010. "Influence of Genetic Background and Tissue Types on Global DNA Methylation Patterns," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-8, February.
    2. Kirsty L. Spalding & Erik Arner & Pål O. Westermark & Samuel Bernard & Bruce A. Buchholz & Olaf Bergmann & Lennart Blomqvist & Johan Hoffstedt & Erik Näslund & Tom Britton & Hernan Concha & Moustapha , 2008. "Dynamics of fat cell turnover in humans," Nature, Nature, vol. 453(7196), pages 783-787, June.
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