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Effect and Safety of Interferon for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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  • Liping Zhuang
  • Xiantao Zeng
  • Zongguo Yang
  • Zhiqiang Meng

Abstract

Background: The effect of interferon(IFN) in the management of hepatocellular carcinoma (HCC) remains controversial, and no clear recommendations have been proposed. Objectives: To evaluate the effect and safety of IFN for HCC. Methods: PubMed, OvidSP, and Cochrane Library were searched from their establishment date until August 30, 2012. Studies that met the inclusion criteria were systematically evaluated and then subjected to meta-analysis. Results: Thirteen randomized control trials (RCTs) involving 1344 patients were eligible for this study. When IFN was used as an adjuvant therapy for HCC patients after curative therapy, the meta-analysis showed that IFN reduced the 1-, 2-, 3-, 4-, and 5-year recurrence rates. Subgroup analysis showed that IFN reduced the 2-, 3-, 4-, and 5-year recurrence rates of hepatitis C viral (HCV)-related HCC. The effect of IFN for on hepatitis B virus(HBV)-related HCC patients could not be determined because of isufficient data. After surgical resection, adjuvant IFN therapy reduced the 4- and 5- recurrence rates. All studies reported that IFN could not improve the overall survival of HCV-realated HCC patients after curative therapies. Only one study showed that IFN was associated with better overall survival in HCC patients after curative therapy and subgroup of HCC patients after surgical resection. Thus, meta-analysis was not performed. Different treatment options were used as control to study the effect of IFN for intermediate and advanced HCC patients, thus meta-analysis was not appropriate. All included studies, except for one, reported that IFN treatment was well tolerated. Conclusions: After curative therapies, adjuvant IFN reduced the recurrence of HCC. IFN did not improve the survival of HCV-related HCC patients after curative therapy. Whether IFN is effective for intermediate and advanced HCC patients could not be determined because of insufficient data. The toxicity of IFN was acceptable.

Suggested Citation

  • Liping Zhuang & Xiantao Zeng & Zongguo Yang & Zhiqiang Meng, 2013. "Effect and Safety of Interferon for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-5, September.
    • Handle: RePEc:plo:pone00:0061361
    DOI: 10.1371/journal.pone.0061361
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Akinori Takaoka & Sumio Hayakawa & Hideyuki Yanai & Dagmar Stoiber & Hideo Negishi & Hideaki Kikuchi & Shigeru Sasaki & Kohzoh Imai & Tsukasa Shibue & Kenya Honda & Tadatsugu Taniguchi, 2003. "Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence," Nature, Nature, vol. 424(6948), pages 516-523, July.
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