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Genetic Variants from Lipid-Related Pathways and Risk for Incident Myocardial Infarction

Author

Listed:
  • Ci Song
  • Nancy L Pedersen
  • Chandra A Reynolds
  • Maria Sabater-Lleal
  • Stavroula Kanoni
  • Christina Willenborg
  • the CARDIoGRAMplusC4D Consortium
  • Ann-Christine Syvänen
  • Hugh Watkins
  • Anders Hamsten
  • Jonathan A Prince
  • Erik Ingelsson

Abstract

Background: Circulating lipids levels, as well as several familial lipid metabolism disorders, are strongly associated with initiation and progression of atherosclerosis and incidence of myocardial infarction (MI). Objectives: We hypothesized that genetic variants associated with circulating lipid levels would also be associated with MI incidence, and have tested this in three independent samples. Setting and Subjects: Using age- and sex-adjusted additive genetic models, we analyzed 554 single nucleotide polymorphisms (SNPs) in 41 candidate gene regions proposed to be involved in lipid-related pathways potentially predisposing to incidence of MI in 2,602 participants of the Swedish Twin Register (STR; 57% women). All associations with nominal P

Suggested Citation

  • Ci Song & Nancy L Pedersen & Chandra A Reynolds & Maria Sabater-Lleal & Stavroula Kanoni & Christina Willenborg & the CARDIoGRAMplusC4D Consortium & Ann-Christine Syvänen & Hugh Watkins & Anders Hamst, 2013. "Genetic Variants from Lipid-Related Pathways and Risk for Incident Myocardial Infarction," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0060454
    DOI: 10.1371/journal.pone.0060454
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    References listed on IDEAS

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    1. Carol H. Gold & Bo Malmberg & Gerald E. McClearn & Nancy L. Pedersen & Stig Berg, 2002. "Gender and Health," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 57(3), pages 168-176.
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    1. Jian-Quan Luo & Jia-Gen Wen & Hong-Hao Zhou & Xiao-Ping Chen & Wei Zhang, 2014. "Endothelial Nitric Oxide Synthase Gene G894T Polymorphism and Myocardial Infarction: A Meta-Analysis of 34 Studies Involving 21068 Subjects," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.

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