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Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India

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  • Kommoju Uma Jyothi
  • Maruda Jayaraj
  • Kadarkarai Samy Subburaj
  • Kotla Jaya Prasad
  • Irgam Kumuda
  • Velaga Lakshmi
  • Battini Mohan Reddy

Abstract

We attempt to evaluate the nature of association of TCF7L2 gene variants with T2DM, for the first time in the population of Hyderabad, which is considered to be diabetic capital of India. It is a case-control study of the three SNPs of TCF7L2, rs7903146, rs12255372 and rs11196205, genotyped on Sequenom Massarray platform, in a sample of 758 patients and 621 controls. The risk allele frequency of the three SNPs was found to be significantly higher in the T2DM cases than controls, implicating susceptibility for diabetes (p

Suggested Citation

  • Kommoju Uma Jyothi & Maruda Jayaraj & Kadarkarai Samy Subburaj & Kotla Jaya Prasad & Irgam Kumuda & Velaga Lakshmi & Battini Mohan Reddy, 2013. "Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0060212
    DOI: 10.1371/journal.pone.0060212
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    References listed on IDEAS

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    1. Robert Sladek & Ghislain Rocheleau & Johan Rung & Christian Dina & Lishuang Shen & David Serre & Philippe Boutin & Daniel Vincent & Alexandre Belisle & Samy Hadjadj & Beverley Balkau & Barbara Heude &, 2007. "A genome-wide association study identifies novel risk loci for type 2 diabetes," Nature, Nature, vol. 445(7130), pages 881-885, February.
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