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Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus

Author

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  • Hongyan Mao
  • Qin Li
  • Shujun Gao

Abstract

Background: A number of case-control studies were conducted to investigate the association of common type 2 diabetes (T2D) risk gene polymorphisms with gestational diabetes mellitus (GDM). However, these studies have yielded contradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between these polymorphisms and GDM, hence achieve a better understanding to the relationship between T2D and GDM. Methods: PubMed, EMBASE, ISI web of science and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to examine the association between 9 polymorphisms from 8 genes and susceptibility to GDM. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Heterogeneity among articles and their publication bias were also tested. Results: We identified 22 eligible studies including a total of 10,336 GDM cases and 17,445 controls. We found 8 genetic polymorphisms were significantly associated with GDM in a random-effects meta-analysis. These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk. Similar results were also observed under dominant genetic model for these polymorphisms. Conclusions: This meta-analysis found 8 genetic variants associated with GDM. The relative contribution and relevance of the identified genes in the pathogenesis of GDM should be the focus of future studies.

Suggested Citation

  • Hongyan Mao & Qin Li & Shujun Gao, 2012. "Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0045882
    DOI: 10.1371/journal.pone.0045882
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    References listed on IDEAS

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    1. Robert Sladek & Ghislain Rocheleau & Johan Rung & Christian Dina & Lishuang Shen & David Serre & Philippe Boutin & Daniel Vincent & Alexandre Belisle & Samy Hadjadj & Beverley Balkau & Barbara Heude &, 2007. "A genome-wide association study identifies novel risk loci for type 2 diabetes," Nature, Nature, vol. 445(7130), pages 881-885, February.
    2. Claudia Ha Ting Tam & Janice Sin Ka Ho & Ying Wang & Heung Man Lee & Vincent Kwok Lim Lam & Soren Germer & Mitchell Martin & Wing Yee So & Ronald Ching Wan Ma & Juliana Chung Ngor Chan & Maggie Chor Y, 2010. "Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects," PLOS ONE, Public Library of Science, vol. 5(7), pages 1-8, July.
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    1. Deng Ao & Hai-jun Wang & Li-fang Wang & Jie-yun Song & Hui-xia Yang & Yan Wang, 2015. "The rs2237892 Polymorphism in KCNQ1 Influences Gestational Diabetes Mellitus and Glucose Levels: A Case-Control Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-11, June.
    2. Pei-Chao Lin & Wei-Ting Lin & Yao-Hsien Yeh & Shu-Fen Wung, 2016. "Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-16, April.

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