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A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Author

Listed:
  • Nicholette D Palmer
  • Caitrin W McDonough
  • Pamela J Hicks
  • Bong H Roh
  • Maria R Wing
  • S Sandy An
  • Jessica M Hester
  • Jessica N Cooke
  • Meredith A Bostrom
  • Megan E Rudock
  • Matthew E Talbert
  • Joshua P Lewis
  • DIAGRAM Consortium
  • MAGIC Investigators
  • Assiamira Ferrara
  • Lingyi Lu
  • Julie T Ziegler
  • Michele M Sale
  • Jasmin Divers
  • Daniel Shriner
  • Adebowale Adeyemo
  • Charles N Rotimi
  • Maggie C Y Ng
  • Carl D Langefeld
  • Barry I Freedman
  • Donald W Bowden

Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Suggested Citation

  • Nicholette D Palmer & Caitrin W McDonough & Pamela J Hicks & Bong H Roh & Maria R Wing & S Sandy An & Jessica M Hester & Jessica N Cooke & Meredith A Bostrom & Megan E Rudock & Matthew E Talbert & Jos, 2012. "A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-14, January.
    • Handle: RePEc:plo:pone00:0029202
    DOI: 10.1371/journal.pone.0029202
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    References listed on IDEAS

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    1. Robert Sladek & Ghislain Rocheleau & Johan Rung & Christian Dina & Lishuang Shen & David Serre & Philippe Boutin & Daniel Vincent & Alexandre Belisle & Samy Hadjadj & Beverley Balkau & Barbara Heude &, 2007. "A genome-wide association study identifies novel risk loci for type 2 diabetes," Nature, Nature, vol. 445(7130), pages 881-885, February.
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    Cited by:

    1. Maggie C Y Ng & Daniel Shriner & Brian H Chen & Jiang Li & Wei-Min Chen & Xiuqing Guo & Jiankang Liu & Suzette J Bielinski & Lisa R Yanek & Michael A Nalls & Mary E Comeau & Laura J Rasmussen-Torvik &, 2014. "Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes," PLOS Genetics, Public Library of Science, vol. 10(8), pages 1-14, August.
    2. Jacob M Keaton & Jacklyn N Hellwege & Maggie C Y Ng & Nicholette D Palmer & James S Pankow & Myriam Fornage & James G Wilson & Adolfo Correa & Laura J Rasmussen-Torvik & Jerome I Rotter & Yii-Der I Ch, 2016. "Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-12, July.

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