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Association between the XRCC1 Polymorphisms and Glioma Risk: A Meta-Analysis of Case-Control Studies

Author

Listed:
  • Lei Jiang
  • Xiao Fang
  • Yi Bao
  • Jue-Yu Zhou
  • Xiao-Yan Shen
  • Mao-Hua Ding
  • Yi Chen
  • Guo-Han Hu
  • Yi-Cheng Lu

Abstract

Background: X-ray repair cross-complementing group 1 (XRCC1) is one of the DNA repair genes encoding a scaffolding protein that participate in base excision repair (BER) pathway. However, studies on the association between polymorphisms in this gene and glioma have yielded conflicting results. This meta-analysis was performed to derive a more precise estimation between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and glioma risk. Methods: Data were collected from several electronic databases, with the last search up to November 28, 2012. Meta-analysis was performed by critically reviewing 9 studies for Arg399Gln polymorphism (3146 cases and 4296 controls), 4 studies for Arg194Trp polymorphism (2557 cases and 4347 controls), and 4 studies for Arg280His polymorphism (1936 cases and 2895 controls). All of the statistical analyses were performed using the software programs STATA (version 11.0). Results: The combined results showed that Arg399Gln polymorphism was significantly associated with glioma risk (Gln/Gln versus Arg/Arg: OR = 1.52, 95% CI = 1.03–2.23; recessive model: OR = 1.32, 95% CI = 1.01–1.73; additive model: OR = 1.21, 95% CI = 1.00–1.47), whereas Arg194Trp/Arg280His polymorphisms were all not significantly associated with glioma risk. As for ethnicity, Arg399Gln polymorphism was associated with increased risk of glioma among Asians (Gln/Gln versus Arg/Arg: OR = 1.78, 95% CI = 1.29–2.47; Arg/Gln versus Arg/Arg: OR = 1.28, 95% CI = 1.05–1.56; recessive model: OR = 1.59, 95% CI = 1.16–2.17; dominant model: OR = 1.36, 95% CI = 1.13–1.65; additive model: OR = 1.32, 95% CI = 1.15–1.52), but not among Caucasians. Stratified analyses by histological subtype indicated that the Gln allele of Arg399Gln polymorphism showed borderline association with the risk of glioblastoma among Caucasians. However, no evidence was observed in subgroup analyses for Arg194Trp/Arg280His polymorphisms. Conclusions: Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.

Suggested Citation

  • Lei Jiang & Xiao Fang & Yi Bao & Jue-Yu Zhou & Xiao-Yan Shen & Mao-Hua Ding & Yi Chen & Guo-Han Hu & Yi-Cheng Lu, 2013. "Association between the XRCC1 Polymorphisms and Glioma Risk: A Meta-Analysis of Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-11, January.
    • Handle: RePEc:plo:pone00:0055597
    DOI: 10.1371/journal.pone.0055597
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    References listed on IDEAS

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    1. Libing Wang & Fan Yin & Xia Xu & Xiaoxia Hu & Dongbao Zhao, 2012. "X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-6, April.
    2. Ya Li & Fei Liu & Shi-Qiao Tan & Yan Wang & Shang-Wei Li, 2012. "X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Cervical Cancer Risk: A HuGE Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-11, September.
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    Cited by:

    1. Li-Wen He & Rong Shi & Lei Jiang & Ye Zeng & Wen-Li Ma & Jue-Yu Zhou, 2014. "XRCC1 Gene Polymorphisms and Glioma Risk in Chinese Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-10, November.
    2. Yadong Wang & Xinwei Chu & Xiaojing Meng & Fei Zou, 2013. "Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-9, October.

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