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Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis

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  • Yadong Wang
  • Xinwei Chu
  • Xiaojing Meng
  • Fei Zou

Abstract

Background: Epidemiologic studies have reported the association of X-ray repair cross-complementary group 1 (XRCC1) Arg399Gln polymorphisms with susceptibility to squamous cell carcinoma of the head and neck (HNSCC). However, the results were conflictive rather than conclusive. The purpose of this study was to clarify the association of XRCC1 Arg399Gln variants with HNSCC risk. Methods: Systematic searches were performed through the search engines of PubMed, Elsevier, Science Direct, CNKI and Chinese Biomedical Literature Database. Summary odds ratio (OR) with 95% confidence intervals (CI) was computed to estimate the strength association. Results: Overall, we did not observe any association of XRCC1 Arg399Gln polymorphisms with HNSCC risk in total population (OR = 0.95, 95% CI: 0.76–1.19 for Gln/Gln vs. Arg/Arg, OR = 1.05, 95% CI: 0.92–1.20 for Arg/Gln vs. Arg/Arg, and OR = 1.03, 95% CI: 0.90–1.18 for Gln/Gln+Arg/Gln vs. Arg/Arg) based on 18 studies including 3917 cases and 4560 controls. In subgroup analyses, we observed an increased risk of XRCC1 399 Arg/Gln genotype for HNSCC in Caucasians (OR = 1.20, 95% CI: 1.00–1.44) and Gln/Gln genotype for larynx squamous cell carcinoma (OR = 1.63, 95% CI: 1.10–2.40). We did not observe any association between XRCC1 Arg399Gln variants and HNSCC risk in additional subgroup analyses. Conclusion: The results from this present meta-analysis suggest that XRCC1 Arg399Gln variants may contribute to HNSCC risk among Caucasians and to the risk of larynx squamous cell carcinoma. Further, well-designed studies with larger sample sizes are required to verify our findings.

Suggested Citation

  • Yadong Wang & Xinwei Chu & Xiaojing Meng & Fei Zou, 2013. "Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-9, October.
    • Handle: RePEc:plo:pone00:0077898
    DOI: 10.1371/journal.pone.0077898
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    References listed on IDEAS

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    1. Caiyun Zhang & Xicheng Song & Minhui Zhu & Song Shi & Meng Li & Lei Jin & Juntian Lang & Guojun Li & Hongliang Zheng, 2013. "Association between MMP1 -1607 1G>2G Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.
    2. Lei Jiang & Xiao Fang & Yi Bao & Jue-Yu Zhou & Xiao-Yan Shen & Mao-Hua Ding & Yi Chen & Guo-Han Hu & Yi-Cheng Lu, 2013. "Association between the XRCC1 Polymorphisms and Glioma Risk: A Meta-Analysis of Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-11, January.
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