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X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Cervical Cancer Risk: A HuGE Systematic Review and Meta-Analysis

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  • Ya Li
  • Fei Liu
  • Shi-Qiao Tan
  • Yan Wang
  • Shang-Wei Li

Abstract

Background: Previous studies investigating the association between X-ray repair cross-complementation group 1(XRCC1) polymorphisms and cervical cancer (CC) risk has provided inconsistent results. The aim of our study was to assess the association between the XRCC1 gene Arg399Gln, Arg194Trp, Arg280His polymorphisms and risk of CC. Methods: Two investigators independently searched the Medline, Embase, CNKI, and Chinese Biomedicine Databases for studies published before March 2011.Summary odds ratios (ORs) and 95% confidence intervals (CIs) for XRCC1 polymorphisms and CC were calculated in a fixed-effects model or a random-effects model when appropriate. Results: Ultimately, 9, 5 and 2 studies were found to be eligible for meta-analyses of Arg399Gln, Arg194Trp and Arg280His, respectively. Our analysis suggested that the variant genotypes of Arg194Trp were associated with a significantly increased CC risk (Trp/Trp vs Arg/Arg, OR = 2.21, 95% CI = 1.60–3.06; Arg/Trp vs Arg/Arg, OR = 1.23, 95% CI = 1.02–1.49; dominant model, OR = 1.36, 95% CI = 1.14–1.63; recessive model, OR = 2.06, 95% CI = 1.51–2.82). For Arg280His polymorphism, no obvious associations were found for all genetic models. For Arg399Gln polymorphism, also no obvious associations were found for all genetic models. In the subgroup analyses by ethnicity/country, a significantly increased risk was observed among Asian, especially among Chinese. To get more precise evidences, adjusted ORs (95%CI) by potential confounders (such as age, ethnicity or smoking, etc) were also calculated for XRCC1 Arg399Gln and Arg194Trp, however, the estimated pooled adjusted OR still did not change at all. Conclusion: This meta-analysis suggests that Arg194Trp polymorphism may be associated with CC risk, Arg399Gln polymorphism might be a low-penetrent risk factor for CC only in Asians, and there may be no association between Arg280His polymorphism and CC risk.

Suggested Citation

  • Ya Li & Fei Liu & Shi-Qiao Tan & Yan Wang & Shang-Wei Li, 2012. "X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Cervical Cancer Risk: A HuGE Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-11, September.
    • Handle: RePEc:plo:pone00:0044441
    DOI: 10.1371/journal.pone.0044441
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    Cited by:

    1. Lei Jiang & Xiao Fang & Yi Bao & Jue-Yu Zhou & Xiao-Yan Shen & Mao-Hua Ding & Yi Chen & Guo-Han Hu & Yi-Cheng Lu, 2013. "Association between the XRCC1 Polymorphisms and Glioma Risk: A Meta-Analysis of Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-11, January.
    2. Tao Bu & Li Liu & Yong Sun & Li Zhao & Yang Peng & Shudong Zhou & Lixia Li & Sidong Chen & Yanhui Gao, 2014. "XRCC1 Arg399Gln Polymorphism Confers Risk of Breast Cancer in American Population: A Meta-Analysis of 10846 Cases and 11723 Controls," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.
    3. Yi Bao & Lei Jiang & Jue-Yu Zhou & Jun-Jie Zou & Jiao-Yang Zheng & Xiang-Fang Chen & Zhi-Min Liu & Yong-Quan Shi, 2013. "XRCC1 Gene Polymorphisms and the Risk of Differentiated Thyroid Carcinoma (DTC): A Meta-Analysis of Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.

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