IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0054018.html
   My bibliography  Save this article

Social Factors and Leukocyte DNA Methylation of Repetitive Sequences: The Multi-Ethnic Study of Atherosclerosis

Author

Listed:
  • Malavika A Subramanyam
  • Ana V Diez-Roux
  • J Richard Pilsner
  • Eduardo Villamor
  • Kathleen M Donohue
  • Yongmei Liu
  • Nancy S Jenny

Abstract

Epigenetic changes are a potential mechanism contributing to race/ethnic and socioeconomic disparities in health. However, there is scant evidence of the race/ethnic and socioeconomic patterning of epigenetic marks. We used data from the Multi-Ethnic Study of Atherosclerosis Stress Study (N = 988) to describe age- and gender- independent associations of race/ethnicity and socioeconomic status (SES) with methylation of Alu and LINE-1 repetitive elements in leukocyte DNA. Mean Alu and Line 1 methylation in the full sample were 24% and 81% respectively. In multivariable linear regression models, African-Americans had 0.27% (p

Suggested Citation

  • Malavika A Subramanyam & Ana V Diez-Roux & J Richard Pilsner & Eduardo Villamor & Kathleen M Donohue & Yongmei Liu & Nancy S Jenny, 2013. "Social Factors and Leukocyte DNA Methylation of Repetitive Sequences: The Multi-Ethnic Study of Atherosclerosis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0054018
    DOI: 10.1371/journal.pone.0054018
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054018
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054018&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0054018?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Braveman, P.A. & Cubbin, C. & Egerter, S. & Williams, D.R. & Pamuk, E., 2010. "Socioeconomic disparities in health in the united States: What the patterns tell us," American Journal of Public Health, American Public Health Association, vol. 100(S1), pages 186-196.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Paul D. Juarez & Mohammad Tabatabai & Robert Burciaga Valdez & Darryl B. Hood & Wansoo Im & Charles Mouton & Cynthia Colen & Mohammad Z. Al-Hamdan & Patricia Matthews-Juarez & Maureen Y. Lichtveld & D, 2020. "The Effects of Social, Personal, and Behavioral Risk Factors and PM 2.5 on Cardio-Metabolic Disparities in a Cohort of Community Health Center Patients," IJERPH, MDPI, vol. 17(10), pages 1-19, May.
    2. Lasse J. Jessen & Sebastian Koehne & Patrick Nüß & Jens Ruhose, 2024. "Socioeconomic Inequality in Life Expectancy: Perception and Policy Demand," CESifo Working Paper Series 10940, CESifo.
    3. Lowe, Kate & Mosby, Kim, 2016. "The conceptual mismatch: A qualitative analysis of transportation costs and stressors for low-income adults," Transport Policy, Elsevier, vol. 49(C), pages 1-8.
    4. Bahram Sanginabadi, 2017. "Resource Abundance and Life Expectancy," Papers 1801.00369, arXiv.org.
    5. Odeyemi Gbenga A., 2015. "Understanding the Dynamics between Income and Health: Evidence Form African’s Richest and Poorest Countries," Journal of Public Policy & Governance, Research Academy of Social Sciences, vol. 2(2), pages 56-67.
    6. Al-Shboul, Mohammad & Al Rawashdeh, Rami, 2022. "The impact of institutional quality and resources rent on health: The case of GCC," Resources Policy, Elsevier, vol. 78(C).
    7. Joan Costa-Font & Frank Cowell & Xuezhu Shi & Joan Costa-i-Font, 2023. "Health Inequality and Health Insurance Coverage: The United States and China Compared," CESifo Working Paper Series 10807, CESifo.
    8. Caitlin Brown & Martin Ravallion, 2023. "Inequality and Social Distancing during the Pandemic," The Journal of Economic Inequality, Springer;Society for the Study of Economic Inequality, vol. 21(3), pages 679-702, September.
    9. Malia Jones & Anne Pebley, 2014. "Redefining Neighborhoods Using Common Destinations: Social Characteristics of Activity Spaces and Home Census Tracts Compared," Demography, Springer;Population Association of America (PAA), vol. 51(3), pages 727-752, June.
    10. Alessandro Rigolon & Matthew H. E. M. Browning & Olivia McAnirlin & Hyunseo (Violet) Yoon, 2021. "Green Space and Health Equity: A Systematic Review on the Potential of Green Space to Reduce Health Disparities," IJERPH, MDPI, vol. 18(5), pages 1-27, March.
    11. Rucker C. Johnson, 2018. "Addressing Racial Health Disparities: Looking Back to Point the Way Forward," The ANNALS of the American Academy of Political and Social Science, , vol. 680(1), pages 132-171, November.
    12. Factor, Roni & Kawachi, Ichiro & Williams, David R., 2011. "Understanding high-risk behavior among non-dominant minorities: A social resistance framework," Social Science & Medicine, Elsevier, vol. 73(9), pages 1292-1301.
    13. Yeshambel T Nigatu & Tara Elton-Marshall & Hayley A Hamilton, 2023. "Changes in household debt due to COVID-19 and mental health concerns among adults in Ontario, Canada," International Journal of Social Psychiatry, , vol. 69(3), pages 774-783, May.
    14. Dai Binh Tran, 2022. "Health Benefits of Education: Comparative Evidence from Vietnam and Thailand," SAGE Open, , vol. 12(2), pages 21582440221, April.
    15. Reanne Frank & Ilana Akresh, 2013. "Social Patterning in Body Mass Index (BMI) Among Contemporary Immigrant Groups: The Emergence of a Gradient," Demography, Springer;Population Association of America (PAA), vol. 50(3), pages 993-1012, June.
    16. Héctor Pifarré i Arolas & Christian Dudel, 2019. "An Ordinal Measure of Population Health," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 143(3), pages 1219-1243, June.
    17. Rachael D. Dombrowski & Bree Bode & Kathryn A. G. Knoff & James Mallare & E. Whitney G. Moore & Noel Kulik, 2021. "Nutrition Supports Deconstructed and Disrupted: An Evaluation of a Multilevel School-Based Intervention during the Time of COVID," IJERPH, MDPI, vol. 18(21), pages 1-16, October.
    18. Jaewon Lee & Jisuk Seon, 2020. "Racial/Ethnic Differences in Health Behaviors and Its Roles on Depressive Symptoms among Young Female Adults," IJERPH, MDPI, vol. 17(19), pages 1-12, October.
    19. Ramseyer Winter, Virginia & Combs, Katie Massey & Ward, Michaella, 2018. "An investigation of the association between foster care, body image, and BMI: A propensity score analysis," Children and Youth Services Review, Elsevier, vol. 84(C), pages 82-85.
    20. Antonios Garas & Sophie Guthmuller & Athanasios Lapatinas, 2021. "The development of nations conditions the disease space," PLOS ONE, Public Library of Science, vol. 16(1), pages 1-35, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0054018. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.