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Association of Increased Frequencies of HLA-DPB1*05∶01 with the Presence of Anti-Ro/SS-A and Anti-La/SS-B Antibodies in Japanese Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients

Author

Listed:
  • Hiroshi Furukawa
  • Shomi Oka
  • Kota Shimada
  • Shoji Sugii
  • Atsushi Hashimoto
  • Akiko Komiya
  • Naoshi Fukui
  • Tatsuo Nagai
  • Shunsei Hirohata
  • Keigo Setoguchi
  • Akira Okamoto
  • Noriyuki Chiba
  • Eiichi Suematsu
  • Taiichiro Miyashita
  • Kiyoshi Migita
  • Akiko Suda
  • Shouhei Nagaoka
  • Naoyuki Tsuchiya
  • Shigeto Tohma

Abstract

Introduction: Autoantibodies to ribonucleoprotein are associated with a variety of autoimmune diseases, including rheumatoid arthritis (RA). Many studies on associations between human leukocyte antigen (HLA) alleles and RA have been reported, but few have been validated in RA subpopulations with anti-La/SS-B or anti-Ro/SS-A antibodies. Here, we investigated associations of HLA class II alleles with the presence of anti-Ro/SS-A or anti-La/SS-B antibodies in RA. Methods: An association study was conducted for HLA-DRB1, DQB1, and DPB1 in Japanese RA and systemic lupus erythematosus (SLE) patients that were positive or negative for anti-Ro/SS-A and/or anti-La/SS-B antibodies. Results: An increased prevalence of certain class II alleles was associated with the presence of anti-Ro/SS-A antibodies as follows: DRB1*08∶03 (Pc = 3.79×10−5, odds ratio [OR] 3.06, 95% confidence interval [CI] 1.98–4.73), DQB1*06∶01 (Pc = 0.0106, OR 1.70, 95%CI 1.26–2.31), and DPB1*05∶01 (Pc = 0.0040, OR 1.55, 95%CI 1.23–1.96). On the other hand, DRB1*15∶01 (Pc = 0.0470, OR 3.14, 95%CI 1.63–6.05), DQB1*06∶02 (Pc = 0.0252, OR 3.14, 95%CI 1.63–6.05), and DPB1*05∶01 (Pc = 0.0069, OR 2.27, 95% CI 1.44–3.57) were associated with anti-La/SS-B antibodies. The DPB1*05∶01 allele was associated with anti-Ro/SS-A (Pc = 0.0408, OR 1.69, 95% CI 1.19–2.41) and anti-La/SS-B antibodies (Pc = 2.48×10−5, OR 3.31, 95%CI 2.02–5.43) in SLE patients. Conclusion: HLA-DPB1*05∶01 was the only allele associated with the presence of both anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese RA and SLE patients.

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  • Hiroshi Furukawa & Shomi Oka & Kota Shimada & Shoji Sugii & Atsushi Hashimoto & Akiko Komiya & Naoshi Fukui & Tatsuo Nagai & Shunsei Hirohata & Keigo Setoguchi & Akira Okamoto & Noriyuki Chiba & Eiich, 2013. "Association of Increased Frequencies of HLA-DPB1*05∶01 with the Presence of Anti-Ro/SS-A and Anti-La/SS-B Antibodies in Japanese Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0053910
    DOI: 10.1371/journal.pone.0053910
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    1. Hiroshi Furukawa & Shomi Oka & Kota Shimada & Shoji Sugii & Jun Ohashi & Toshihiro Matsui & Tatsuoh Ikenaka & Hisanori Nakayama & Atsushi Hashimoto & Hirokazu Takaoka & Yoshiyuki Arinuma & Yuko Okazak, 2012. "Association of Human Leukocyte Antigen with Interstitial Lung Disease in Rheumatoid Arthritis: A Protective Role for Shared Epitope," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-7, May.
    2. Stephanie N Lewis & Elaine Nsoesie & Charles Weeks & Dan Qiao & Liqing Zhang, 2011. "Prediction of Disease and Phenotype Associations from Genome-Wide Association Studies," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-10, November.
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    1. Shomi Oka & Hiroshi Furukawa & Aya Kawasaki & Kota Shimada & Shoji Sugii & Atsushi Hashimoto & Akiko Komiya & Naoshi Fukui & Satoshi Ito & Tadashi Nakamura & Koichiro Saisho & Masao Katayama & Shinich, 2014. "Protective Effect of the HLA-DRB1*13:02 Allele in Japanese Rheumatoid Arthritis Patients," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-12, June.

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