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Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations

Author

Listed:
  • Hiroshi Furukawa
  • Shomi Oka
  • Kota Shimada
  • Atsushi Hashimoto
  • Akiko Komiya
  • Shinichiro Tsunoda
  • Akiko Suda
  • Satoshi Ito
  • Koichiro Saisho
  • Masao Katayama
  • Satoshi Shinohara
  • Takeo Sato
  • Katsuya Nagatani
  • Seiji Minota
  • Toshihiro Matsui
  • Naoshi Fukui
  • Shoji Sugii
  • Hajime Sano
  • Kiyoshi Migita
  • Shouhei Nagaoka
  • Shigeto Tohma

Abstract

Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations. Methods: Association analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls. Results: In unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16–1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (Padjusted = 0.0003, Pcadjusted = 0.0040, ORadjusted 1.47, 95%CI 1.19–1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65–0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected. Conclusion: The independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified.

Suggested Citation

  • Hiroshi Furukawa & Shomi Oka & Kota Shimada & Atsushi Hashimoto & Akiko Komiya & Shinichiro Tsunoda & Akiko Suda & Satoshi Ito & Koichiro Saisho & Masao Katayama & Satoshi Shinohara & Takeo Sato & Kat, 2018. "Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0204459
    DOI: 10.1371/journal.pone.0204459
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    References listed on IDEAS

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    1. Stephanie N Lewis & Elaine Nsoesie & Charles Weeks & Dan Qiao & Liqing Zhang, 2011. "Prediction of Disease and Phenotype Associations from Genome-Wide Association Studies," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-10, November.
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