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Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families

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  • Ary Gadelha
  • Vanessa Kiyomi Ota
  • Jose Paya Cano
  • Maria Isabel Melaragno
  • Marilia A C Smith
  • Jair de Jesus Mari
  • Rodrigo A Bressan
  • Sintia Iole Belangero
  • Gerome Breen

Abstract

We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN® software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63–92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4–14 cM. Of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia.

Suggested Citation

  • Ary Gadelha & Vanessa Kiyomi Ota & Jose Paya Cano & Maria Isabel Melaragno & Marilia A C Smith & Jair de Jesus Mari & Rodrigo A Bressan & Sintia Iole Belangero & Gerome Breen, 2012. "Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-6, December.
    • Handle: RePEc:plo:pone00:0052262
    DOI: 10.1371/journal.pone.0052262
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    1. Sukanta Saha & David Chant & Joy Welham & John McGrath, 2005. "A Systematic Review of the Prevalence of Schizophrenia," PLOS Medicine, Public Library of Science, vol. 2(5), pages 1-1, May.
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