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African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts

Author

Listed:
  • Ching-Yu Cheng
  • David Reich
  • Christopher A Haiman
  • Arti Tandon
  • Nick Patterson
  • Selvin Elizabeth
  • Ermeg L Akylbekova
  • Frederick L Brancati
  • Josef Coresh
  • Eric Boerwinkle
  • David Altshuler
  • Herman A Taylor
  • Brian E Henderson
  • James G Wilson
  • W H Linda Kao

Abstract

The risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that genetic factors may explain some of this population difference in disease risk. However, relatively few genetic studies have examined this hypothesis in a large sample of African Americans with and without diabetes. Therefore, we performed an admixture analysis using 2,189 ancestry-informative markers in 7,021 African Americans (2,373 with type 2 diabetes and 4,648 without) from the Atherosclerosis Risk in Communities Study, the Jackson Heart Study, and the Multiethnic Cohort to 1) determine the association of type 2 diabetes and its related quantitative traits with African ancestry controlling for measures of SES and 2) identify genetic loci for type 2 diabetes through a genome-wide admixture mapping scan. The median percentage of African ancestry of diabetic participants was slightly greater than that of non-diabetic participants (study-adjusted difference = 1.6%, P

Suggested Citation

  • Ching-Yu Cheng & David Reich & Christopher A Haiman & Arti Tandon & Nick Patterson & Selvin Elizabeth & Ermeg L Akylbekova & Frederick L Brancati & Josef Coresh & Eric Boerwinkle & David Altshuler & H, 2012. "African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0032840
    DOI: 10.1371/journal.pone.0032840
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    References listed on IDEAS

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    1. Robert Sladek & Ghislain Rocheleau & Johan Rung & Christian Dina & Lishuang Shen & David Serre & Philippe Boutin & Daniel Vincent & Alexandre Belisle & Samy Hadjadj & Beverley Balkau & Barbara Heude &, 2007. "A genome-wide association study identifies novel risk loci for type 2 diabetes," Nature, Nature, vol. 445(7130), pages 881-885, February.
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