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Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts

Author

Listed:
  • Vesna Boraska
  • Aaron Day-Williams
  • Christopher S Franklin
  • Katherine S Elliott
  • Kalliope Panoutsopoulou
  • Ioanna Tachmazidou
  • Eva Albrecht
  • Stefania Bandinelli
  • Lawrence J Beilin
  • Murielle Bochud
  • Gemma Cadby
  • Florian Ernst
  • David M Evans
  • Caroline Hayward
  • Andrew A Hicks
  • Jennifer Huffman
  • Cornelia Huth
  • Alan L James
  • Norman Klopp
  • Ivana Kolcic
  • Zoltán Kutalik
  • Debbie A Lawlor
  • Arthur W Musk
  • Marina Pehlic
  • Craig E Pennell
  • John R B Perry
  • Annette Peters
  • Ozren Polasek
  • Beate St Pourcain
  • Susan M Ring
  • Erika Salvi
  • Sabine Schipf
  • Jan A Staessen
  • Alexander Teumer
  • Nicholas Timpson
  • Veronique Vitart
  • Nicole M Warrington
  • Hanieh Yaghootkar
  • Tatijana Zemunik
  • Lina Zgaga
  • Ping An
  • Verneri Anttila
  • Ingrid B Borecki
  • Jostein Holmen
  • Ioanna Ntalla
  • Aarno Palotie
  • Kirsi H Pietiläinen
  • Juho Wedenoja
  • Bendik S Winsvold
  • George V Dedoussis
  • Jaakko Kaprio
  • Michael A Province
  • John-Anker Zwart
  • Michel Burnier
  • Harry Campbell
  • Daniele Cusi
  • George Davey Smith
  • Timothy M Frayling
  • Christian Gieger
  • Lyle J Palmer
  • Peter P Pramstaller
  • Igor Rudan
  • Henry Völzke
  • H -Erich Wichmann
  • Alan F Wright
  • Eleftheria Zeggini

Abstract

Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p

Suggested Citation

  • Vesna Boraska & Aaron Day-Williams & Christopher S Franklin & Katherine S Elliott & Kalliope Panoutsopoulou & Ioanna Tachmazidou & Eva Albrecht & Stefania Bandinelli & Lawrence J Beilin & Murielle Boc, 2012. "Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0031369
    DOI: 10.1371/journal.pone.0031369
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    References listed on IDEAS

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    1. Benedetta Bartali & Enrico Benvenuti & Anna Maria Corsi & Stefania Bandinelli & Cosimo Roberto Russo & Angelo Di Iorio & Fulvio Lauretani & Luigi Ferrucci, 2002. "Changes in anthropometric measures in men and women across the life-span: findings from the inCHIANTI study," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 47(5), pages 336-348, November.
    2. Julia Fischer & Linda Koch & Christian Emmerling & Jeanette Vierkotten & Thomas Peters & Jens C. Brüning & Ulrich Rüther, 2009. "Inactivation of the Fto gene protects from obesity," Nature, Nature, vol. 458(7240), pages 894-898, April.
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