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Inactivation of the Fto gene protects from obesity

Author

Listed:
  • Julia Fischer

    (Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany)

  • Linda Koch

    (Department of Mouse Genetics and Metabolism, Institute for Genetics and Second Department of Internal Medicine,
    Center of Molecular Medicine Cologne (CMMC) and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Germany
    Max-Planck Institute for the Biology of Ageing)

  • Christian Emmerling

    (Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany)

  • Jeanette Vierkotten

    (Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany
    Present addresses: Department of Dermatology, Center of Molecular Medicine Cologne (CMMC), University of Cologne, D-50674 Cologne, Germany (J.V.); Epidauros Biotechnologie AG, D-82347 Bernried, Germany (T.P.).)

  • Thomas Peters

    (Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany
    Present addresses: Department of Dermatology, Center of Molecular Medicine Cologne (CMMC), University of Cologne, D-50674 Cologne, Germany (J.V.); Epidauros Biotechnologie AG, D-82347 Bernried, Germany (T.P.).)

  • Jens C. Brüning

    (Department of Mouse Genetics and Metabolism, Institute for Genetics and Second Department of Internal Medicine,
    Center of Molecular Medicine Cologne (CMMC) and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Germany
    Max-Planck Institute for the Biology of Ageing)

  • Ulrich Rüther

    (Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany)

Abstract

Protection from obesity Variations in the human FTO gene have been linked to obesity-related traits in several genome-wide association studies. A functional correlation is now reported between Fto, the equivalent gene in the mouse, and obesity. In Fto-deficient mice there is postnatal growth retardation and a lean phenotype with high energy expenditure and reduced fat accumulation. This suggests that Fto/FTO is involved in homeostasis via the control of energy expenditure.

Suggested Citation

  • Julia Fischer & Linda Koch & Christian Emmerling & Jeanette Vierkotten & Thomas Peters & Jens C. Brüning & Ulrich Rüther, 2009. "Inactivation of the Fto gene protects from obesity," Nature, Nature, vol. 458(7240), pages 894-898, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7240:d:10.1038_nature07848
    DOI: 10.1038/nature07848
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    Cited by:

    1. Christopher G Bell & Sarah Finer & Cecilia M Lindgren & Gareth A Wilson & Vardhman K Rakyan & Andrew E Teschendorff & Pelin Akan & Elia Stupka & Thomas A Down & Inga Prokopenko & Ian M Morison & Jonat, 2010. "Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-12, November.
    2. von Hinke Kessler Scholder S, 2009. "Genetic Markers as Instrumental Variables: An Application to Child Fat Mass and Academic Achievement," Health, Econometrics and Data Group (HEDG) Working Papers 09/25, HEDG, c/o Department of Economics, University of York.
    3. Moshe Shay Ben-Haim & Yishay Pinto & Sharon Moshitch-Moshkovitz & Vera Hershkovitz & Nitzan Kol & Tammy Diamant-Levi & Michal Schnaider Beeri & Ninette Amariglio & Haim Y. Cohen & Gideon Rechavi, 2021. "Dynamic regulation of N6,2′-O-dimethyladenosine (m6Am) in obesity," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Ulla Sovio & Dennis O Mook-Kanamori & Nicole M Warrington & Robert Lawrence & Laurent Briollais & Colin N A Palmer & Joanne Cecil & Johanna K Sandling & Ann-Christine Syvänen & Marika Kaakinen & Lawri, 2011. "Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development," PLOS Genetics, Public Library of Science, vol. 7(2), pages 1-13, February.
    5. X. Tao & X.M. Men & B. Deng & Z.W. Xu, 2013. "Effects of breed, postnatal development, and nutrition on mRNA expression of the FTO gene in porcine muscle and its relationship with intramuscular fat deposition," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 58(8), pages 381-388.
    6. Vesna Boraska & Aaron Day-Williams & Christopher S Franklin & Katherine S Elliott & Kalliope Panoutsopoulou & Ioanna Tachmazidou & Eva Albrecht & Stefania Bandinelli & Lawrence J Beilin & Murielle Boc, 2012. "Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-10, March.
    7. Chibo Liu & Sihua Mou & Yangqun Cai, 2013. "FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    8. Song-Yao Zhang & Shao-Wu Zhang & Lian Liu & Jia Meng & Yufei Huang, 2016. "m6A-Driver: Identifying Context-Specific mRNA m6A Methylation-Driven Gene Interaction Networks," PLOS Computational Biology, Public Library of Science, vol. 12(12), pages 1-31, December.
    9. Sujun Yan & Xiaoling Zhou & Canlan Wu & Yunyi Gao & Yu Qian & Jingyu Hou & Renxiang Xie & Bing Han & Zhanghui Chen & Saisai Wei & Xiangwei Gao, 2023. "Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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