IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0030309.html
   My bibliography  Save this article

Contribution of HOGG1 Ser326Cys Polymorphism to the Development of Prostate Cancer in Smokers: Meta-Analysis of 2779 Cases and 3484 Controls

Author

Listed:
  • Bin Xu
  • Na Tong
  • Shu-Qiu Chen
  • Yu Yang
  • Xiao-Wen Zhang
  • Jin Liu
  • Xiang-Nong Hu
  • Guo-Zhu Sha
  • Ming Chen

Abstract

The HOGG1 gene catalyzes the excision of modified bases and removal of DNA damage adducts. It may play an important role in the prevention of carcinogenesis. Ser326Cys polymorphism localizes in exon 7 of the hOGG1 gene. It takes the form of an amino acid substitution, from serine to cysteine, in codon 326. Several epidemiological association studies have been conducted on this polymorphism and its relationship with the risk of prostate cancer. However, results have been conflicting. To resolve this conflict, we conducted a meta-analysis on the association between this polymorphism and prostate cancer, taking into account race, country, sources of controls, and smoking status. A total of nine studies covering 2779 cases and 3484 controls were included in the current meta-analysis. Although no significant association was found between hOGG1 Ser326Cys polymorphism and prostate cancer susceptibility in the pooled analysis, individuals with Ser/Cys+Cys/Cys genotypes were found to have greater risk of prostate cancer if they were also smokers (OR = 2.66, 95% CI = 1.58−4.47) rather than non-smokers (OR = 2.18, 95% CI = 1.13−4.19), compared with those with Ser/Ser genotype. In conclusion, our meta-analysis demonstrates that hOGG1 Ser326Cys polymorphism is a risk factor for prostate cancer in smokers. Further studies are needed to confirm this relationship.

Suggested Citation

  • Bin Xu & Na Tong & Shu-Qiu Chen & Yu Yang & Xiao-Wen Zhang & Jin Liu & Xiang-Nong Hu & Guo-Zhu Sha & Ming Chen, 2012. "Contribution of HOGG1 Ser326Cys Polymorphism to the Development of Prostate Cancer in Smokers: Meta-Analysis of 2779 Cases and 3484 Controls," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0030309
    DOI: 10.1371/journal.pone.0030309
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030309
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030309&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0030309?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Huncharek, M. & Sue Haddock, K. & Reid, R. & Kupelnick, B., 2010. "Smoking as a risk factor for prostate cancer: A meta-analysis of 24 prospective cohort studies," American Journal of Public Health, American Public Health Association, vol. 100(4), pages 693-701.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mohammad Al Qadire & Murad Alkhalaileh & Mohammed ALBashtawy, 2019. "Lifestyle and Dietary Factors and Prostate Cancer Risk: A Multicentre Case-Control Study," Clinical Nursing Research, , vol. 28(8), pages 992-1008, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0030309. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.