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The Effects of Cognitive Therapy versus ‘No Intervention’ for Major Depressive Disorder

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  • Janus Christian Jakobsen
  • Jane Lindschou Hansen
  • Ole Jakob Storebø
  • Erik Simonsen
  • Christian Gluud

Abstract

Background: Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Cognitive therapy may be an effective treatment option for major depressive disorder, but the effects have only had limited assessment in systematic reviews. Methods/Principal Findings: We used The Cochrane systematic review methodology with meta-analyses and trial sequential analyses of randomized trials comparing the effects of cognitive therapy versus ‘no intervention’ for major depressive disorder. Participants had to be older than 17 years with a primary diagnosis of major depressive disorder to be eligible. Altogether, we included 12 trials randomizing a total of 669 participants. All 12 trials had high risk of bias. Meta-analysis on the Hamilton Rating Scale for Depression showed that cognitive therapy significantly reduced depressive symptoms (four trials; mean difference −3.05 (95% confidence interval (Cl), −5.23 to −0.87; P

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  • Janus Christian Jakobsen & Jane Lindschou Hansen & Ole Jakob Storebø & Erik Simonsen & Christian Gluud, 2011. "The Effects of Cognitive Therapy versus ‘No Intervention’ for Major Depressive Disorder," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0028299
    DOI: 10.1371/journal.pone.0028299
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    Cited by:

    1. Kotaro Imamura & Norito Kawakami & Toshi A Furukawa & Yutaka Matsuyama & Akihito Shimazu & Rino Umanodan & Sonoko Kawakami & Kiyoto Kasai, 2014. "Effects of an Internet-Based Cognitive Behavioral Therapy (iCBT) Program in Manga Format on Improving Subthreshold Depressive Symptoms among Healthy Workers: A Randomized Controlled Trial," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-13, May.
    2. Tomonari Irie & Kengo Yokomitsu & Yuji Sakano, 2019. "Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-30, September.

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