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Interactions between Genetic Variants in the Adiponectin, Adiponectin Receptor 1 and Environmental Factors on the Risk of Colorectal Cancer

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  • Li Liu
  • Rong Zhong
  • Sheng Wei
  • Jie-Yun Yin
  • Hao Xiang
  • Li Zou
  • Wei Chen
  • Ji-Gui Chen
  • Xia-Wen Zheng
  • Li-Juan Huang
  • Bei-Bei Zhu
  • Quan Chen
  • Sheng-Yu Duan
  • Rui Rui
  • Bei-Fang Yang
  • Jing-Wen Sun
  • Duo-Shuang Xie
  • Yi-Hua Xu
  • Xiao-Ping Miao
  • Shao-Fa Nie

Abstract

Background: Metabolic syndrome traits play an important role in the development of colorectal cancer. Adipokines, key metabolic syndrome cellular mediators, when abnormal, may induce carcinogenesis. Methodology/Principal Findings: To investigate whether polymorphisms of important adipokines, adiponectin (ADIPOQ) and its receptors, either alone or in combination with environmental factors, are implicated in colorectal cancer, a two-stage case-control study was conducted. In the first stage, we evaluated 24 tag single nucleotide polymorphisms (tag SNPs) across ADIPOQ ligand and two ADIPOQ receptors (ADIPOR1 and ADIPOR2) among 470 cases and 458 controls. One SNP with promising association was then analyzed in stage 2 among 314 cases and 355 controls. In our study, ADIPOQ rs1063538 was consistently associated with increased colorectal cancer risk, with an odds ratio (OR) of 1.94 (95%CI: 1.48–2.54) for CC genotype compared with TT genotype. In two-factor gene-environment interaction analyses, rs1063538 presented significant interactions with smoking status, family history of cancer and alcohol use, with ORs of 4.52 (95%CI: 2.78–7.34), 3.18 (95%CI: 1.73–5.82) and 1.97 (95%CI: 1.27–3.04) for smokers, individuals with family history of cancer or drinkers with CC genotype compared with non-smokers, individuals without family history of cancer or non-drinkers with TT genotype, respectively. Multifactor gene-environment interactions analysis revealed significant interactions between ADIPOQ rs1063538, ADIPOR1 rs1539355, smoking status and BMI. Individuals carrying one, two and at least three risk factors presented 1.18–fold (95%CI:0.89–fold to 1.58–fold), 1.87–fold (95%CI: 1.38–fold to2.54–fold) and 4.39–fold (95%CI: 2.75–fold to 7.01–fold) increased colorectal cancer risk compared with those who without risk factor, respectively (P trend

Suggested Citation

  • Li Liu & Rong Zhong & Sheng Wei & Jie-Yun Yin & Hao Xiang & Li Zou & Wei Chen & Ji-Gui Chen & Xia-Wen Zheng & Li-Juan Huang & Bei-Bei Zhu & Quan Chen & Sheng-Yu Duan & Rui Rui & Bei-Fang Yang & Jing-W, 2011. "Interactions between Genetic Variants in the Adiponectin, Adiponectin Receptor 1 and Environmental Factors on the Risk of Colorectal Cancer," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-9, November.
  • Handle: RePEc:plo:pone00:0027301
    DOI: 10.1371/journal.pone.0027301
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    1. Toshimasa Yamauchi & Junji Kamon & Yusuke Ito & Atsushi Tsuchida & Takehiko Yokomizo & Shunbun Kita & Takuya Sugiyama & Makoto Miyagishi & Kazuo Hara & Masaki Tsunoda & Koji Murakami & Toshiaki Ohteki, 2003. "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects," Nature, Nature, vol. 423(6941), pages 762-769, June.
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    1. Li Liu & Rong Zhong & Sheng Wei & Hao Xiang & Jigui Chen & Duoshuang Xie & Jieyun Yin & Li Zou & Jingwen Sun & Wei Chen & Xiaoping Miao & Shaofa Nie, 2013. "The Leptin Gene Family and Colorectal Cancer: Interaction with Smoking Behavior and Family History of Cancer," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.

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