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The Leptin Gene Family and Colorectal Cancer: Interaction with Smoking Behavior and Family History of Cancer

Author

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  • Li Liu
  • Rong Zhong
  • Sheng Wei
  • Hao Xiang
  • Jigui Chen
  • Duoshuang Xie
  • Jieyun Yin
  • Li Zou
  • Jingwen Sun
  • Wei Chen
  • Xiaoping Miao
  • Shaofa Nie

Abstract

Background: Pathologic condition associated with metabolic syndrome traits seems to increase the risk of colorectal cancer. One mechanism underlying this relationship may involve the growth-promoting effects of the circulation hormones associated with obesity and insulin resistance, such as leptin. Methodology/Principal Findings: A two-stage case-control study was used to explore the role of polymorphisms of Leptin (LEP) and Leptin receptor (LEPR), either alone or in combination with environmental factors in colorectal carcinogenesis. In stage 1, 20 single nucleotide polymorphisms (SNPs) that tag common SNPs in these two genes were genotyped among 470 cases and 458 controls. In stage 2, another population with 314 cases and 355 controls were genotyped for the two most promising SNPs from stage 1. LEPR rs12037879 only presented modestly increased colorectal cancer risk, with odds ratios of 1.41 (95% confidence interval [CI] 1.13–1.76) and 1.74 (95%CI 1.08–2.81) for GA and AA genotype when compared with GG genotype in combined population. Smokers carrying LEPR rs12037879 A allele presented 1.67-fold (95%CI 1.39-fold to 2.01-fold) increased colorectal cancer risk when compared with non-smokers carrying GG genotype in combined analysis. Individuals with family history of cancer harboring LEPR rs12037879 A allele showed 1.52-fold (95%CI: 1.24-fold to 1.86-fold) increased colorectal cancer risk, compared with individuals without family history of cancer harboring GG genotype. Multifactor gene-environment interaction analysis revealed significant interactions among LEPR rs12037879, LEPR rs6690625, smoking status and family history of cancer, exhibiting a gradient of increased colorectal cancer risk along with the increasing number of risk factors (P = 9.82×10−10). Conclusions/Significance: Our research supports that polymorphisms in LEPR may be associated with marginal increase in the risk for colorectal cancer. Moreover, this association could be strengthened by cigarette smoking and family history of cancer.

Suggested Citation

  • Li Liu & Rong Zhong & Sheng Wei & Hao Xiang & Jigui Chen & Duoshuang Xie & Jieyun Yin & Li Zou & Jingwen Sun & Wei Chen & Xiaoping Miao & Shaofa Nie, 2013. "The Leptin Gene Family and Colorectal Cancer: Interaction with Smoking Behavior and Family History of Cancer," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0060777
    DOI: 10.1371/journal.pone.0060777
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    1. Li Liu & Rong Zhong & Sheng Wei & Jie-Yun Yin & Hao Xiang & Li Zou & Wei Chen & Ji-Gui Chen & Xia-Wen Zheng & Li-Juan Huang & Bei-Bei Zhu & Quan Chen & Sheng-Yu Duan & Rui Rui & Bei-Fang Yang & Jing-W, 2011. "Interactions between Genetic Variants in the Adiponectin, Adiponectin Receptor 1 and Environmental Factors on the Risk of Colorectal Cancer," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-9, November.
    2. Carola Marzi & Eva Albrecht & Pirro G Hysi & Vasiliki Lagou & Melanie Waldenberger & Anke Tönjes & Inga Prokopenko & Katharina Heim & Hannah Blackburn & Janina S Ried & Marcus E Kleber & Massimo Mangi, 2010. "Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A," PLOS Genetics, Public Library of Science, vol. 6(11), pages 1-8, November.
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