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An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome

Author

Listed:
  • Shixuan Liu

    (Stanford University School of Medicine
    Stanford University School of Medicine
    Howard Hughes Medical Institute)

  • Camille Ezran

    (Stanford University School of Medicine
    Howard Hughes Medical Institute)

  • Michael F. Z. Wang

    (Meinig School of Biomedical Engineering, Cornell University)

  • Zhengda Li

    (Stanford University School of Medicine)

  • Kyle Awayan

    (Chan Zuckerberg Biohub)

  • Jonathan Z. Long

    (Stanford University School of Medicine
    Sarafan ChEM-H)

  • Iwijn De Vlaminck

    (Meinig School of Biomedical Engineering, Cornell University)

  • Sheng Wang

    (University of Washington)

  • Jacques Epelbaum

    (National Center for Scientific Research, National Museum of Natural History)

  • Christin S. Kuo

    (Stanford University School of Medicine)

  • Jérémy Terrien

    (National Center for Scientific Research, National Museum of Natural History)

  • Mark A. Krasnow

    (Stanford University School of Medicine
    Howard Hughes Medical Institute)

  • James E. Ferrell

    (Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, hormone signaling by its very nature connects cells of different organs and involves crosstalk of different hormones. Here, we leverage the organism-wide single cell transcriptional atlas of a non-human primate, the mouse lemur (Microcebus murinus), to systematically map source and target cells for 84 classes of hormones. This work uncovers previously-uncharacterized sites of hormone regulation, and shows that the hormonal signaling network is densely connected, decentralized, and rich in feedback loops. Evolutionary comparisons of hormonal genes and their expression patterns show that mouse lemur better models human hormonal signaling than mouse, at both the genomic and transcriptomic levels, and reveal primate-specific rewiring of hormone-producing/target cells. This work complements the scale and resolution of classical endocrine studies and sheds light on primate hormone regulation.

Suggested Citation

  • Shixuan Liu & Camille Ezran & Michael F. Z. Wang & Zhengda Li & Kyle Awayan & Jonathan Z. Long & Iwijn De Vlaminck & Sheng Wang & Jacques Epelbaum & Christin S. Kuo & Jérémy Terrien & Mark A. Krasnow , 2024. "An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome," Nature Communications, Nature, vol. 15(1), pages 1-27, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46070-9
    DOI: 10.1038/s41467-024-46070-9
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