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Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol

Author

Listed:
  • Kristjana Hrönn Ásbjörnsdóttir
  • Sitara S Rao Ajjampur
  • Roy M Anderson
  • Robin Bailey
  • Iain Gardiner
  • Katherine E Halliday
  • Moudachirou Ibikounle
  • Khumbo Kalua
  • Gagandeep Kang
  • D Timothy J Littlewood
  • Adrian J F Luty
  • Arianna Rubin Means
  • William Oswald
  • Rachel L Pullan
  • Rajiv Sarkar
  • Fabian Schär
  • Adam Szpiro
  • James E Truscott
  • Marleen Werkman
  • Elodie Yard
  • Judd L Walson
  • The DeWorm3 Trials Team

Abstract

Trial registration: ClinicalTrials.gov NCT03014167 Author summary: Soil-transmitted helminths (STH) affect 1.45 billion people worldwide, and high intensity infections are associated with anemia, undernutrition and impaired cognition, particularly among children. Mathematical models suggest it may be possible to interrupt the transmission of STH in a community by expanding mass drug administration (MDA) from targeted high-risk groups (primarily school-aged children and women of child-bearing age) to all community members with high coverage. The DeWorm3 Project will test the feasibility of this approach to interrupting the transmission of STH using a series of cluster randomized trials in Benin, India and Malawi. Each study area (population ≥80,000) will be divided into 40 clusters and randomized to community-wide or standard-of-care targeted MDA for three years. Two years following the final round of MDA, prevalence of STH will be compared between arms and transmission interruption assessed in each cluster. The DeWorm3 trials will provide stakeholders with information regarding the potential to switch from STH control to a more ambitious and sustainable strategy.

Suggested Citation

  • Kristjana Hrönn Ásbjörnsdóttir & Sitara S Rao Ajjampur & Roy M Anderson & Robin Bailey & Iain Gardiner & Katherine E Halliday & Moudachirou Ibikounle & Khumbo Kalua & Gagandeep Kang & D Timothy J Litt, 2018. "Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 12(1), pages 1-16, January.
    • Handle: RePEc:plo:pntd00:0006166
    DOI: 10.1371/journal.pntd.0006166
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    References listed on IDEAS

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    1. Tie-Wu Jia & Sara Melville & Jürg Utzinger & Charles H King & Xiao-Nong Zhou, 2012. "Soil-Transmitted Helminth Reinfection after Drug Treatment: A Systematic Review and Meta-Analysis," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 6(5), pages 1-11, May.
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