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Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

Author

Listed:
  • Jingjing Liang
  • Thu H Le
  • Digna R Velez Edwards
  • Bamidele O Tayo
  • Kyle J Gaulton
  • Jennifer A Smith
  • Yingchang Lu
  • Richard A Jensen
  • Guanjie Chen
  • Lisa R Yanek
  • Karen Schwander
  • Salman M Tajuddin
  • Tamar Sofer
  • Wonji Kim
  • James Kayima
  • Colin A McKenzie
  • Ervin Fox
  • Michael A Nalls
  • J Hunter Young
  • Yan V Sun
  • Jacqueline M Lane
  • Sylvia Cechova
  • Jie Zhou
  • Hua Tang
  • Myriam Fornage
  • Solomon K Musani
  • Heming Wang
  • Juyoung Lee
  • Adebowale Adeyemo
  • Albert W Dreisbach
  • Terrence Forrester
  • Pei-Lun Chu
  • Anne Cappola
  • Michele K Evans
  • Alanna C Morrison
  • Lisa W Martin
  • Kerri L Wiggins
  • Qin Hui
  • Wei Zhao
  • Rebecca D Jackson
  • Erin B Ware
  • Jessica D Faul
  • Alex P Reiner
  • Michael Bray
  • Joshua C Denny
  • Thomas H Mosley
  • Walter Palmas
  • Xiuqing Guo
  • George J Papanicolaou
  • Alan D Penman
  • Joseph F Polak
  • Kenneth Rice
  • Ken D Taylor
  • Eric Boerwinkle
  • Erwin P Bottinger
  • Kiang Liu
  • Neil Risch
  • Steven C Hunt
  • Charles Kooperberg
  • Alan B Zonderman
  • Cathy C Laurie
  • Diane M Becker
  • Jianwen Cai
  • Ruth J F Loos
  • Bruce M Psaty
  • David R Weir
  • Sharon L R Kardia
  • Donna K Arnett
  • Sungho Won
  • Todd L Edwards
  • Susan Redline
  • Richard S Cooper
  • D C Rao
  • Jerome I Rotter
  • Charles Rotimi
  • Daniel Levy
  • Aravinda Chakravarti
  • Xiaofeng Zhu
  • Nora Franceschini

Abstract

Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies. These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P

Suggested Citation

  • Jingjing Liang & Thu H Le & Digna R Velez Edwards & Bamidele O Tayo & Kyle J Gaulton & Jennifer A Smith & Yingchang Lu & Richard A Jensen & Guanjie Chen & Lisa R Yanek & Karen Schwander & Salman M Taj, 2017. "Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations," PLOS Genetics, Public Library of Science, vol. 13(5), pages 1-22, May.
    • Handle: RePEc:plo:pgen00:1006728
    DOI: 10.1371/journal.pgen.1006728
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    References listed on IDEAS

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    2. Ya-Juan Wang & Bamidele O Tayo & Anupam Bandyopadhyay & Heming Wang & Tao Feng & Nora Franceschini & Hua Tang & Jianmin Gao & Yun Ju Sung & the COGENT BP consortium & Robert C Elston & Scott M William, 2014. "The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function," PLOS Genetics, Public Library of Science, vol. 10(9), pages 1-12, September.
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