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Genetic Heterogeneity of Susceptibility Gene in Different Ethnic Populations: Refining Association Study of PTPN22 for Graves’ Disease in a Chinese Han Population

Author

Listed:
  • Liqiong Xue
  • Chunming Pan
  • Zhaohui Gu
  • Shuangxia Zhao
  • Bing Han
  • Wei Liu
  • Shaoying Yang
  • Shasha Yu
  • Yixuan Sun
  • Jun Liang
  • Guanqi Gao
  • Xiaomei Zhang
  • Guoyue Yuan
  • Changgui Li
  • Wenhua Du
  • Gang Chen
  • Jialun Chen
  • Huaidong Song

Abstract

In our previous studies, we presumed subtypes of Graves’ disease (GD) may be caused by different major susceptibility genes or different variants of a single susceptibility gene. However, more evidence is needed to support this hypothesis. Single-nucleotide polymorphism (SNP) rs2476601 in PTPN22 is the susceptibility loci of GD in the European population. However, this polymorphism has not been found in Asian populations. Here, we investigate whether PTPN22 is the susceptibility gene for GD in Chinese population and further determine the susceptibility variant of PTPN22 in GD. We conducted an imputation analysis based on the results of our genome-wide association study (GWAS) in 1,536 GD patients and 1,516 control subjects. Imputation revealed that 255 common SNPs on a linkage disequilibrium (LD) block containing PTPN22 were associated with GD (P 0.05) in either the genotype distribution or allelic frequencies between patients and controls in the replication study. Although the combined analysis exhibited a weak association signal (Pcombined = 0.003263 for rs3811021), the false positive report probability (FPRP) analysis indicated it was most likely a false positive finding. Our study did not support an association of common SNPs in PTPN22 LD block with GD in Chinese Han population. This suggests that GD in different ethnic population is probably caused by distinct susceptibility genes.

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  • Liqiong Xue & Chunming Pan & Zhaohui Gu & Shuangxia Zhao & Bing Han & Wei Liu & Shaoying Yang & Shasha Yu & Yixuan Sun & Jun Liang & Guanqi Gao & Xiaomei Zhang & Guoyue Yuan & Changgui Li & Wenhua Du , 2013. "Genetic Heterogeneity of Susceptibility Gene in Different Ethnic Populations: Refining Association Study of PTPN22 for Graves’ Disease in a Chinese Han Population," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    • Handle: RePEc:plo:pone00:0084514
    DOI: 10.1371/journal.pone.0084514
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    References listed on IDEAS

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