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Functional Translational Readthrough: A Systems Biology Perspective

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  • Fabian Schueren
  • Sven Thoms

Abstract

Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing translation of the mRNA downstream of the stop codon. Here we review recent developments in TR research with a focus on the identification of FTR in humans and the systems biology methods that have spurred these discoveries.

Suggested Citation

  • Fabian Schueren & Sven Thoms, 2016. "Functional Translational Readthrough: A Systems Biology Perspective," PLOS Genetics, Public Library of Science, vol. 12(8), pages 1-12, August.
    • Handle: RePEc:plo:pgen00:1006196
    DOI: 10.1371/journal.pgen.1006196
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    1. Andrew P. Carter & William M. Clemons & Ditlev E. Brodersen & Robert J. Morgan-Warren & Brian T. Wimberly & V. Ramakrishnan, 2000. "Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics," Nature, Nature, vol. 407(6802), pages 340-348, September.
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