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Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
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Abstract
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR
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DOI: 10.1371/journal.pgen.1003500
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- William R Scott & Weihua Zhang & Marie Loh & Sian-Tsung Tan & Benjamin Lehne & Uzma Afzal & Juan Peralta & Richa Saxena & Sarju Ralhan & Gurpreet S Wander & Kiymet Bozaoglu & Dharambir K Sanghera & Pa, 2016. "Investigation of Genetic Variation Underlying Central Obesity amongst South Asians," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-17, May.
- Keira J A Johnston & Joey Ward & Pradipta R Ray & Mark J Adams & Andrew M McIntosh & Blair H Smith & Rona J Strawbridge & Theodore J Price & Daniel J Smith & Barbara I Nicholl & Mark E S Bailey, 2021. "Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank," PLOS Genetics, Public Library of Science, vol. 17(4), pages 1-27, April.
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