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The Economics of Reproducibility in Preclinical Research

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  • Leonard P Freedman
  • Iain M Cockburn
  • Timothy S Simcoe

Abstract

Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approximately US$28,000,000,000 (US$28B)/year spent on preclinical research that is not reproducible—in the United States alone. We outline a framework for solutions and a plan for long-term improvements in reproducibility rates that will help to accelerate the discovery of life-saving therapies and cures.This Perspective provides estimates of the rate of irreproducibility of preclinical research and its direct cost implications. It goes on to outline a framework for solutions and a plan for long-term improvements in reproducibility rates.

Suggested Citation

  • Leonard P Freedman & Iain M Cockburn & Timothy S Simcoe, 2015. "The Economics of Reproducibility in Preclinical Research," PLOS Biology, Public Library of Science, vol. 13(6), pages 1-9, June.
    • Handle: RePEc:plo:pbio00:1002165
    DOI: 10.1371/journal.pbio.1002165
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