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The emergence of Zika virus and its new clinical syndromes

Author

Listed:
  • Theodore C. Pierson

    (National Institutes of Health)

  • Michael S. Diamond

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

Abstract

Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health threat because of its potential to generate explosive epidemics and ability to cause congenital disease in the context of infection during pregnancy. Whereas much is known about the biology of related flaviviruses, the unique features of ZIKV pathogenesis, including infection of the fetus, persistence in immune-privileged sites and sexual transmission, have presented new challenges. The rapid development of cell culture and animal models has facilitated a new appreciation of ZIKV biology. This knowledge has created opportunities for the development of countermeasures, including multiple ZIKV vaccine candidates, which are advancing through clinical trials. Here we describe the recent advances that have led to a new understanding of the causes and consequences of the ZIKV epidemic.

Suggested Citation

  • Theodore C. Pierson & Michael S. Diamond, 2018. "The emergence of Zika virus and its new clinical syndromes," Nature, Nature, vol. 560(7720), pages 573-581, August.
    • Handle: RePEc:nat:nature:v:560:y:2018:i:7720:d:10.1038_s41586-018-0446-y
    DOI: 10.1038/s41586-018-0446-y
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    Cited by:

    1. Raphaëlle Klitting & Liana E. Kafetzopoulou & Wim Thiery & Gytis Dudas & Sophie Gryseels & Anjali Kotamarthi & Bram Vrancken & Karthik Gangavarapu & Mambu Momoh & John Demby Sandi & Augustine Goba & F, 2022. "Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Yanxia Huang & Qinyu Peng & Xu Tian & Cancan Chen & Xuanfeng Zhu & Changbai Huang & Zhiting Huo & Yang Liu & Chao Yang & Chao Liu & Ping Zhang, 2024. "Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Marie-Christine Vaney & Mariano Dellarole & Stéphane Duquerroy & Iris Medits & Georgios Tsouchnikas & Alexander Rouvinski & Patrick England & Karin Stiasny & Franz X. Heinz & Félix A. Rey, 2022. "Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Xinglong Liu & Zhengfeng Li & Xiaoxia Li & Weixuan Wu & Huadong Jiang & Yufen Zheng & Junjie Zhou & Xianmiao Ye & Junnan Lu & Wei Wang & Lei Yu & Yiping Li & Linbing Qu & Jianhua Wang & Feng Li & Ling, 2024. "A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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