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Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

Author

Listed:
  • Li He

    (Harvard Medical School)

  • Guangwei Si

    (Center for Brain Science, Harvard University)

  • Jiuhong Huang

    (School of Life Science and Technology, Tongji University)

  • Aravinthan D. T. Samuel

    (Center for Brain Science, Harvard University)

  • Norbert Perrimon

    (Harvard Medical School
    Howard Hughes Medical Institute)

Abstract

Stem cells of the Drosophila midgut sense mechanical signals in vivo through the stretch-activated ion channel Piezo, which is expressed on previously unidentified enteroendocrine precursor cells.

Suggested Citation

  • Li He & Guangwei Si & Jiuhong Huang & Aravinthan D. T. Samuel & Norbert Perrimon, 2018. "Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel," Nature, Nature, vol. 555(7694), pages 103-106, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7694:d:10.1038_nature25744
    DOI: 10.1038/nature25744
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    Cited by:

    1. Nolan Frey & Utku M. Sönmez & Jonathan Minden & Philip LeDuc, 2022. "Microfluidics for understanding model organisms," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Jiae Lee & Alejandra J. H. Cabrera & Cecilia M. T. Nguyen & Young V. Kwon, 2020. "Dissemination of RasV12-transformed cells requires the mechanosensitive channel Piezo," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    3. Ahmad Mayeli & Obada Al Zoubi & Evan J. White & Sheridan Chappelle & Rayus Kuplicki & Alexa Morton & Jaimee Bruce & Ryan Smith & Justin S. Feinstein & Jerzy Bodurka & Martin P. Paulus & Sahib S. Khals, 2023. "Parieto-occipital ERP indicators of gut mechanosensation in humans," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Kathyani Parasram & Amy Zuccato & Minjeong Shin & Reegan Willms & Brian DeVeale & Edan Foley & Phillip Karpowicz, 2024. "The emergence of circadian timekeeping in the intestine," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Junjun Gao & Song Zhang & Pan Deng & Zhigang Wu & Bruno Lemaitre & Zongzhao Zhai & Zheng Guo, 2024. "Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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