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Dissemination of RasV12-transformed cells requires the mechanosensitive channel Piezo

Author

Listed:
  • Jiae Lee

    (University of Washington)

  • Alejandra J. H. Cabrera

    (University of Washington)

  • Cecilia M. T. Nguyen

    (University of Washington)

  • Young V. Kwon

    (University of Washington)

Abstract

Dissemination of transformed cells is a key process in metastasis. Despite its importance, how transformed cells disseminate from an intact tissue and enter the circulation is poorly understood. Here, we use a fully developed tissue, Drosophila midgut, and describe the morphologically distinct steps and the cellular events occurring over the course of RasV12-transformed cell dissemination. Notably, RasV12-transformed cells formed the Actin- and Cortactin-rich invasive protrusions that were important for breaching the extracellular matrix (ECM) and visceral muscle. Furthermore, we uncovered the essential roles of the mechanosensory channel Piezo in orchestrating dissemination of RasV12-transformed cells. Collectively, our study establishes an in vivo model for studying how transformed cells migrate out from a complex tissue and provides unique insights into the roles of Piezo in invasive cell behavior.

Suggested Citation

  • Jiae Lee & Alejandra J. H. Cabrera & Cecilia M. T. Nguyen & Young V. Kwon, 2020. "Dissemination of RasV12-transformed cells requires the mechanosensitive channel Piezo," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17341-y
    DOI: 10.1038/s41467-020-17341-y
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    References listed on IDEAS

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    1. Li He & Guangwei Si & Jiuhong Huang & Aravinthan D. T. Samuel & Norbert Perrimon, 2018. "Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel," Nature, Nature, vol. 555(7694), pages 103-106, March.
    2. Sung Eun Kim & Bertrand Coste & Abhishek Chadha & Boaz Cook & Ardem Patapoutian, 2012. "The role of Drosophila Piezo in mechanical nociception," Nature, Nature, vol. 483(7388), pages 209-212, March.
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    Cited by:

    1. Daniel Jun-Kit Hu & Jina Yun & Justin Elstrott & Heinrich Jasper, 2021. "Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Clement Verkest & Irina Schaefer & Timo A. Nees & Na Wang & Juri M. Jegelka & Francisco J. Taberner & Stefan G. Lechner, 2022. "Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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