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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Author

Listed:
  • Matthew J. Hangauer

    (University of California San Francisco
    UCSF Diabetes Center, University of California San Francisco
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • Vasanthi S. Viswanathan

    (Broad Institute)

  • Matthew J. Ryan

    (Broad Institute)

  • Dhruv Bole

    (UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • John K. Eaton

    (Broad Institute)

  • Alexandre Matov

    (DataSet Analysis LLC)

  • Jacqueline Galeas

    (UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • Harshil D. Dhruv

    (The Translational Genomics Research Institute)

  • Michael E. Berens

    (The Translational Genomics Research Institute)

  • Stuart L. Schreiber

    (Broad Institute
    Howard Hughes Medical Institute
    Harvard University)

  • Frank McCormick

    (UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)

  • Michael T. McManus

    (University of California San Francisco
    UCSF Diabetes Center, University of California San Francisco)

Abstract

Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4.

Suggested Citation

  • Matthew J. Hangauer & Vasanthi S. Viswanathan & Matthew J. Ryan & Dhruv Bole & John K. Eaton & Alexandre Matov & Jacqueline Galeas & Harshil D. Dhruv & Michael E. Berens & Stuart L. Schreiber & Frank , 2017. "Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition," Nature, Nature, vol. 551(7679), pages 247-250, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7679:d:10.1038_nature24297
    DOI: 10.1038/nature24297
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    Cited by:

    1. Jun Jiang & Lili Yang & Qianqian Xie & Xi Liu & Jie Jiang & Jie Zhang & Shuping Zhang & Huizhen Zheng & Wenjie Li & Xiaoming Cai & Sijin Liu & Ruibin Li, 2024. "Synthetic vectors for activating the driving axis of ferroptosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Jun Dai & Shuyu Zheng & Matías M. Falco & Jie Bao & Johanna Eriksson & Sanna Pikkusaari & Sofia Forstén & Jing Jiang & Wenyu Wang & Luping Gao & Fernando Perez-Villatoro & Olli Dufva & Khalid Saeed & , 2024. "Tracing back primed resistance in cancer via sister cells," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Sarah Figarol & Célia Delahaye & Rémi Gence & Aurélia Doussine & Juan Pablo Cerapio & Mathylda Brachais & Claudine Tardy & Nicolas Béry & Raghda Asslan & Jacques Colinge & Jean-Philippe Villemin & Ant, 2024. "Farnesyltransferase inhibition overcomes oncogene-addicted non-small cell lung cancer adaptive resistance to targeted therapies," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Keith Woodley & Laura S. Dillingh & George Giotopoulos & Pedro Madrigal & Kevin M. Rattigan & Céline Philippe & Vilma Dembitz & Aoife M. S. Magee & Ryan Asby & Louie N. van de Lagemaat & Christopher M, 2023. "Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    5. Heike Chauvistré & Batool Shannan & Sheena M. Daignault-Mill & Robert J. Ju & Daniel Picard & Stefanie Egetemaier & Renáta Váraljai & Christine S. Gibhardt & Antonio Sechi & Farnusch Kaschani & Oliver, 2022. "Persister state-directed transitioning and vulnerability in melanoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Mihee Oh & Seo Young Jang & Ji-Yoon Lee & Jong Woo Kim & Youngae Jung & Jiwoo Kim & Jinho Seo & Tae-Su Han & Eunji Jang & Hye Young Son & Dain Kim & Min Wook Kim & Jin-Sung Park & Kwon-Ho Song & Kyoun, 2023. "The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    7. Dadi Jiang & Youming Guo & Tianyu Wang & Liang Wang & Yuelong Yan & Ling Xia & Rakesh Bam & Zhifen Yang & Hyemin Lee & Takao Iwawaki & Boyi Gan & Albert C. Koong, 2024. "IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    8. Pranavi Koppula & Guang Lei & Yilei Zhang & Yuelong Yan & Chao Mao & Lavanya Kondiparthi & Jiejun Shi & Xiaoguang Liu & Amber Horbath & Molina Das & Wei Li & Masha V. Poyurovsky & Kellen Olszewski & B, 2022. "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Bartosz Wiernicki & Sophia Maschalidi & Jonathan Pinney & Sandy Adjemian & Tom Vanden Berghe & Kodi S. Ravichandran & Peter Vandenabeele, 2022. "Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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