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Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites

Author

Listed:
  • Asaf Poran

    (Institute for Computational Biomedicine, Weill Cornell Medicine
    Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine
    Physiology, Biophysics and Systems Biology Graduate Program, Weill Cornell Medicine)

  • Christopher Nötzel

    (Biochemistry, Cell & Molecular Biology Graduate Program, Weill Cornell Medicine
    Weill Cornell Medicine)

  • Omar Aly

    (Institute for Computational Biomedicine, Weill Cornell Medicine
    Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine)

  • Nuria Mencia-Trinchant

    (Weill Cornell Medicine)

  • Chantal T. Harris

    (Weill Cornell Medicine
    Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine)

  • Monica L. Guzman

    (Weill Cornell Medicine)

  • Duane C. Hassane

    (Institute for Computational Biomedicine, Weill Cornell Medicine
    Weill Cornell Medicine)

  • Olivier Elemento

    (Institute for Computational Biomedicine, Weill Cornell Medicine
    Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine)

  • Björn F. C. Kafsack

    (Weill Cornell Medicine)

Abstract

Highly parallel single-cell transcriptome profiling of Plasmodium falciparum blood stages provides insight into the role AP2-G plays in early sexual development of this eukaryotic pathogen.

Suggested Citation

  • Asaf Poran & Christopher Nötzel & Omar Aly & Nuria Mencia-Trinchant & Chantal T. Harris & Monica L. Guzman & Duane C. Hassane & Olivier Elemento & Björn F. C. Kafsack, 2017. "Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites," Nature, Nature, vol. 551(7678), pages 95-99, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7678:d:10.1038_nature24280
    DOI: 10.1038/nature24280
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    Citations

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    Cited by:

    1. Mubasher Mohammed & Alexis Dziedziech & Diego Macedo & Frederik Huppertz & Ylva Veith & Zoé Postel & Elena Christ & Richard Scheytt & Tanja Slotte & Johan Henriksson & Johan Ankarklev, 2024. "Single-cell transcriptomics reveal transcriptional programs underlying male and female cell fate during Plasmodium falciparum gametocytogenesis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Nicholas L. Dooley & Tinashe G. Chabikwa & Zuleima Pava & Jessica R. Loughland & Julianne Hamelink & Kiana Berry & Dean Andrew & Megan S. F. Soon & Arya SheelaNair & Kim A. Piera & Timothy William & B, 2023. "Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    3. Brittany Hazzard & Juliana M. Sá & Haikel N. Bogale & Tales V. Pascini & Angela C. Ellis & Shuchi Amin & Jennifer S. Armistead & John H. Adams & Thomas E. Wellems & David Serre, 2024. "Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Jaishree Tripathi & Lei Zhu & Sourav Nayak & Michal Stoklasa & Zbynek Bozdech, 2022. "Stochastic expression of invasion genes in Plasmodium falciparum schizonts," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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