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Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots

Author

Listed:
  • Titiwat Sungkaworn

    (Institute of Pharmacology and Toxicology, University of Würzburg
    Bio-Imaging Center/Rudolf Virchow Center, University of Würzburg)

  • Marie-Lise Jobin

    (Institute of Pharmacology and Toxicology, University of Würzburg
    Bio-Imaging Center/Rudolf Virchow Center, University of Würzburg)

  • Krzysztof Burnecki

    (Faculty of Pure and Applied Mathematics, Hugo Steinhaus Center, Wroclaw University of Science and Technology)

  • Aleksander Weron

    (Faculty of Pure and Applied Mathematics, Hugo Steinhaus Center, Wroclaw University of Science and Technology)

  • Martin J. Lohse

    (Institute of Pharmacology and Toxicology, University of Würzburg
    Bio-Imaging Center/Rudolf Virchow Center, University of Würzburg
    Max Delbrück Center for Molecular Medicine)

  • Davide Calebiro

    (Institute of Pharmacology and Toxicology, University of Würzburg
    Bio-Imaging Center/Rudolf Virchow Center, University of Würzburg
    Institute of Metabolism and Systems Research, University of Birmingham
    Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham)

Abstract

G-protein-coupled receptors and their G protein partners are studied by single-molecule imaging in living cells, which reveals hot spots on the cell membrane where receptors and G proteins interact and signal.

Suggested Citation

  • Titiwat Sungkaworn & Marie-Lise Jobin & Krzysztof Burnecki & Aleksander Weron & Martin J. Lohse & Davide Calebiro, 2017. "Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots," Nature, Nature, vol. 550(7677), pages 543-547, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7677:d:10.1038_nature24264
    DOI: 10.1038/nature24264
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    Citations

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    Cited by:

    1. Okrasińska-Płociniczak, Hanna & Płociniczak, Łukasz, 2022. "Second order scheme for self-similar solutions of a time-fractional porous medium equation on the half-line," Applied Mathematics and Computation, Elsevier, vol. 424(C).
    2. Muszkieta, Monika & Janczura, Joanna & Weron, Aleksander, 2021. "Simulation and tracking of fractional particles motion. From microscopy video to statistical analysis. A Brownian bridge approach," Applied Mathematics and Computation, Elsevier, vol. 396(C).
    3. Yong-Seok Kim & Jun-Hee Yeon & Woori Ko & Byung-Chang Suh, 2023. "Two-step structural changes in M3 muscarinic receptor activation rely on the coupled Gq protein cycle," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Loch-Olszewska, Hanna, 2019. "Properties and distribution of the dynamical functional for the fractional Gaussian noise," Applied Mathematics and Computation, Elsevier, vol. 356(C), pages 252-271.
    5. Marie-Lise Jobin & Sana Siddig & Zsombor Koszegi & Yann Lanoiselée & Vladimir Khayenko & Titiwat Sungkaworn & Christian Werner & Kerstin Seier & Christin Misigaiski & Giovanna Mantovani & Markus Sauer, 2023. "Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Nathan Bénac & G. Ezequiel Saraceno & Corey Butler & Nahoko Kuga & Yuya Nishimura & Taiki Yokoi & Ping Su & Takuya Sasaki & Mar Petit-Pedrol & Rémi Galland & Vincent Studer & Fang Liu & Yuji Ikegaya &, 2024. "Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    7. Muszkieta, Monika & Janczura, Joanna, 2023. "A compressed sensing approach to interpolation of fractional Brownian trajectories for a single particle tracking experiment," Applied Mathematics and Computation, Elsevier, vol. 446(C).
    8. Christian Niederauer & Chikim Nguyen & Miles Wang-Henderson & Johannes Stein & Sebastian Strauss & Alexander Cumberworth & Florian Stehr & Ralf Jungmann & Petra Schwille & Kristina A. Ganzinger, 2023. "Dual-color DNA-PAINT single-particle tracking enables extended studies of membrane protein interactions," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    9. Tobias Benkel & Mirjam Zimmermann & Julian Zeiner & Sergi Bravo & Nicole Merten & Victor Jun Yu Lim & Edda Sofie Fabienne Matthees & Julia Drube & Elke Miess-Tanneberg & Daniela Malan & Martyna Szpako, 2022. "How Carvedilol activates β2-adrenoceptors," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    10. Julia Ast & Daniela Nasteska & Nicholas H. F. Fine & Daniel J. Nieves & Zsombor Koszegi & Yann Lanoiselée & Federica Cuozzo & Katrina Viloria & Andrea Bacon & Nguyet T. Luu & Philip N. Newsome & David, 2023. "Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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