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PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

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  • Sydney R. Gordon

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine)

  • Roy L. Maute

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Ben W. Dulken

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Stanford Medical Scientist Training Program, Stanford University)

  • Gregor Hutter

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Stanford University School of Medicine
    University Hospital Basel)

  • Benson M. George

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Melissa N. McCracken

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Rohit Gupta

    (Human Immune Monitoring Center Biobank, Stanford University School of Medicine)

  • Jonathan M. Tsai

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Rahul Sinha

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Daniel Corey

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

  • Aaron M. Ring

    (Yale University School of Medicine)

  • Andrew J. Connolly

    (Stanford University Medical Center)

  • Irving L. Weissman

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
    Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine
    Stanford Cancer Institute, Stanford University School of Medicine
    Stanford University Medical Center)

Abstract

Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast, PD-L1 removal increases phagocytosis in vivo, decreases tumour burden and increases survival of mice.

Suggested Citation

  • Sydney R. Gordon & Roy L. Maute & Ben W. Dulken & Gregor Hutter & Benson M. George & Melissa N. McCracken & Rohit Gupta & Jonathan M. Tsai & Rahul Sinha & Daniel Corey & Aaron M. Ring & Andrew J. Conn, 2017. "PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity," Nature, Nature, vol. 545(7655), pages 495-499, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7655:d:10.1038_nature22396
    DOI: 10.1038/nature22396
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    Cited by:

    1. Chih-Wei Chou & Chia-Nung Hung & Cheryl Hsiang-Ling Chiu & Xi Tan & Meizhen Chen & Chien-Chin Chen & Moawiz Saeed & Che-Wei Hsu & Michael A. Liss & Chiou-Miin Wang & Zhao Lai & Nathaniel Alvarez & Paw, 2023. "Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Yonghyun Lee & Jongyoon Shinn & Cheng Xu & Hannah E. Dobson & Nouri Neamati & James J. Moon, 2023. "Hyaluronic acid-bilirubin nanomedicine-based combination chemoimmunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Xudong Wang & Siyu Su & Yuqing Zhu & Xiaolong Cheng & Chen Cheng & Leilei Chen & Anhua Lei & Li Zhang & Yuyan Xu & Dan Ye & Yi Zhang & Wei Li & Jin Zhang, 2023. "Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Mokarram Hossain & Raymond Shim & Woo-Yong Lee & Arlene H. Sharpe & Paul Kubes, 2022. "Gata6+ resident peritoneal macrophages promote the growth of liver metastasis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Shiqun Wang & Wei Yan & Lingkai Kong & Shuguang Zuo & Jingyi Wu & Chunxiao Zhu & Huaping Huang & Bohao He & Jie Dong & Jiwu Wei, 2023. "Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    6. Tian Lan & Fengwei Gao & Yunshi Cai & Yinghao Lv & Jiang Zhu & Hu Liu & Sinan Xie & Haifeng Wan & Haorong He & Kunlin Xie & Chang Liu & Hong Wu, 2025. "The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment," Nature Communications, Nature, vol. 16(1), pages 1-22, December.

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