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Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Author

Listed:
  • Prasenjit Dey

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Joelle Baddour

    (Rice University)

  • Florian Muller

    (The University of Texas MD Anderson Cancer Center)

  • Chia Chin Wu

    (The University of Texas MD Anderson Cancer Center)

  • Huamin Wang

    (The University of Texas MD Anderson Cancer Center)

  • Wen-Ting Liao

    (The University of Texas MD Anderson Cancer Center)

  • Zangdao Lan

    (The University of Texas MD Anderson Cancer Center)

  • Alina Chen

    (The University of Texas MD Anderson Cancer Center)

  • Tony Gutschner

    (The University of Texas MD Anderson Cancer Center)

  • Yaan Kang

    (The University of Texas MD Anderson Cancer Center)

  • Jason Fleming

    (The University of Texas MD Anderson Cancer Center)

  • Nikunj Satani

    (The University of Texas MD Anderson Cancer Center)

  • Di Zhao

    (The University of Texas MD Anderson Cancer Center)

  • Abhinav Achreja

    (Rice University)

  • Lifeng Yang

    (Rice University)

  • Jiyoon Lee

    (Rice University)

  • Edward Chang

    (The University of Texas MD Anderson Cancer Center
    Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Giannicola Genovese

    (The University of Texas MD Anderson Cancer Center)

  • Andrea Viale

    (The University of Texas MD Anderson Cancer Center)

  • Haoqiang Ying

    (The University of Texas MD Anderson Cancer Center)

  • Giulio Draetta

    (The University of Texas MD Anderson Cancer Center
    Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Anirban Maitra

    (The University of Texas MD Anderson Cancer Center
    Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center)

  • Y. Alan Wang

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Deepak Nagrath

    (Rice University)

  • Ronald A. DePinho

    (The University of Texas MD Anderson Cancer Center)

Abstract

Depletion of malic enzyme 3 in pancreatic cancer cells that have a deletion of the gene for malic enzyme 2 selectively kills the cells, suggesting that the enzyme might represent a therapeutic target for this subset of cancers.

Suggested Citation

  • Prasenjit Dey & Joelle Baddour & Florian Muller & Chia Chin Wu & Huamin Wang & Wen-Ting Liao & Zangdao Lan & Alina Chen & Tony Gutschner & Yaan Kang & Jason Fleming & Nikunj Satani & Di Zhao & Abhinav, 2017. "Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer," Nature, Nature, vol. 542(7639), pages 119-123, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7639:d:10.1038_nature21052
    DOI: 10.1038/nature21052
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    Cited by:

    1. Taiqi Chen & Siyi Xie & Jie Cheng & Qiao Zhao & Hong Wu & Peng Jiang & Wenjing Du, 2024. "AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Nazanin Esmaeili Anvar & Chenchu Lin & Xingdi Ma & Lori L. Wilson & Ryan Steger & Annabel K. Sangree & Medina Colic & Sidney H. Wang & John G. Doench & Traver Hart, 2024. "Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Yimiao Feng & Yahui Long & He Wang & Yang Ouyang & Quan Li & Min Wu & Jie Zheng, 2024. "Benchmarking machine learning methods for synthetic lethality prediction in cancer," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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