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From morphogen to morphogenesis and back

Author

Listed:
  • Darren Gilmour

    (European Molecular Biology Laboratory)

  • Martina Rembold

    (Institute for Genetics, University of Cologne
    Present address: European Molecular Biology Organization, 69117 Heidelberg, Germany.)

  • Maria Leptin

    (European Molecular Biology Laboratory
    Institute for Genetics, University of Cologne)

Abstract

A long-term aim of the life sciences is to understand how organismal shape is encoded by the genome. An important challenge is to identify mechanistic links between the genes that control cell-fate decisions and the cellular machines that generate shape, therefore closing the gap between genotype and phenotype. The logic and mechanisms that integrate these different levels of shape control are beginning to be described, and recently discovered mechanisms of cross-talk and feedback are beginning to explain the remarkable robustness of organ assembly. The 'full-circle' understanding of morphogenesis that is emerging, besides solving a key puzzle in biology, provides a mechanistic framework for future approaches to tissue engineering.

Suggested Citation

  • Darren Gilmour & Martina Rembold & Maria Leptin, 2017. "From morphogen to morphogenesis and back," Nature, Nature, vol. 541(7637), pages 311-320, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7637:d:10.1038_nature21348
    DOI: 10.1038/nature21348
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    Cited by:

    1. Hannah J. Gustafson & Nikolas Claussen & Stefano Renzis & Sebastian J. Streichan, 2022. "Patterned mechanical feedback establishes a global myosin gradient," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Lijuan Du & Alex Sohr & Yujia Li & Sougata Roy, 2022. "GPI-anchored FGF directs cytoneme-mediated bidirectional contacts to regulate its tissue-specific dispersion," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Aurélien Villedieu & Lale Alpar & Isabelle Gaugué & Amina Joudat & François Graner & Floris Bosveld & Yohanns Bellaïche, 2023. "Homeotic compartment curvature and tension control spatiotemporal folding dynamics," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Anchel de Jaime-Soguero & Janina Hattemer & Anja Bufe & Alexander Haas & Jeroen Berg & Vincent Batenburg & Biswajit Das & Barbara Marco & Stefania Androulaki & Nicolas Böhly & Jonathan J. M. Landry & , 2024. "Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    5. Amrita Singh & Sameedha Thale & Tobias Leibner & Lucas Lamparter & Andrea Ricker & Harald Nüsse & Jürgen Klingauf & Milos Galic & Mario Ohlberger & Maja Matis, 2024. "Dynamic interplay of microtubule and actomyosin forces drive tissue extension," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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