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Atomic structure of the entire mammalian mitochondrial complex I

Author

Listed:
  • Karol Fiedorczuk

    (Institute of Science and Technology Austria
    MRC Mitochondrial Biology Unit)

  • James A. Letts

    (Institute of Science and Technology Austria)

  • Gianluca Degliesposti

    (MRC Laboratory of Molecular Biology)

  • Karol Kaszuba

    (Institute of Science and Technology Austria)

  • Mark Skehel

    (MRC Laboratory of Molecular Biology)

  • Leonid A. Sazanov

    (Institute of Science and Technology Austria)

Abstract

The atomic structure of ovine mitochondrial complex I is solved at 3.9 Å resolution, revealing that supernumerary subunits stabilize the complex and providing insight into the molecular basis of its function and regulation.

Suggested Citation

  • Karol Fiedorczuk & James A. Letts & Gianluca Degliesposti & Karol Kaszuba & Mark Skehel & Leonid A. Sazanov, 2016. "Atomic structure of the entire mammalian mitochondrial complex I," Nature, Nature, vol. 538(7625), pages 406-410, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7625:d:10.1038_nature19794
    DOI: 10.1038/nature19794
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    Cited by:

    1. Fangzhu Han & Yiqi Hu & Mengchen Wu & Zhaoxiang He & Hongtao Tian & Long Zhou, 2023. "Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. M. Tanvir Rahman & M. Kristian Koski & Joanna Panecka-Hofman & Werner Schmitz & Alexander J. Kastaniotis & Rebecca C. Wade & Rik K. Wierenga & J. Kalervo Hiltunen & Kaija J. Autio, 2023. "An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Enrique Balderas & David R. Eberhardt & Sandra Lee & John M. Pleinis & Salah Sommakia & Anthony M. Balynas & Xue Yin & Mitchell C. Parker & Colin T. Maguire & Scott Cho & Marta W. Szulik & Anna Bakhti, 2022. "Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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