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A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter

Author

Listed:
  • Michael L. Oldham

    (The Rockefeller University
    Howard Hughes Medical Institute)

  • Richard K. Hite

    (The Rockefeller University
    Howard Hughes Medical Institute)

  • Alanna M. Steffen

    (Howard Hughes Medical Institute)

  • Ermelinda Damko

    (The Rockefeller University)

  • Zongli Li

    (Howard Hughes Medical Institute
    Harvard Medical School)

  • Thomas Walz

    (The Rockefeller University)

  • Jue Chen

    (The Rockefeller University
    Howard Hughes Medical Institute)

Abstract

The cryo-electron microscopy structure of human TAP transporter, a peptide transporter central to MHC class I antigen presentation and cellular immunity, in complex with the herpes simplex virus protein ICP47.

Suggested Citation

  • Michael L. Oldham & Richard K. Hite & Alanna M. Steffen & Ermelinda Damko & Zongli Li & Thomas Walz & Jue Chen, 2016. "A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter," Nature, Nature, vol. 529(7587), pages 537-540, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7587:d:10.1038_nature16506
    DOI: 10.1038/nature16506
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    Cited by:

    1. Jun Gyou Park & Songwon Kim & Eunhong Jang & Seung Hun Choi & Hyunsu Han & Seulgi Ju & Ji Won Kim & Da Sol Min & Mi Sun Jin, 2022. "The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Nitesh Kumar Khandelwal & Thomas M. Tomasiak, 2024. "Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Ying Huang & Chenyang Xue & Ruiqian Bu & Cang Wu & Jiachen Li & Jinqiu Zhang & Jinyu Chen & Zhaoying Shi & Yonglong Chen & Yong Wang & Zhongmin Liu, 2024. "Inhibition and transport mechanisms of the ABC transporter hMRP5," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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