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Diet-induced extinctions in the gut microbiota compound over generations

Author

Listed:
  • Erica D. Sonnenburg

    (Stanford University School of Medicine)

  • Samuel A. Smits

    (Stanford University School of Medicine)

  • Mikhail Tikhonov

    (Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University
    Kavli Institute for Bionano Science and Technology, Harvard University)

  • Steven K. Higginbottom

    (Stanford University School of Medicine)

  • Ned S. Wingreen

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Justin L. Sonnenburg

    (Stanford University School of Medicine)

Abstract

In mice on a low microbiota-accessible carbohydrate (MAC) diet, the diversity of the gut microbiota is depleted, and the effect is transferred and compounded over generations; this phenotype is only reversed after supplementation of the missing taxa via faecal microbiota transplantation, suggesting dietary intervention alone may by insufficient at managing diseases characterized by a dysbiotic microbiota.

Suggested Citation

  • Erica D. Sonnenburg & Samuel A. Smits & Mikhail Tikhonov & Steven K. Higginbottom & Ned S. Wingreen & Justin L. Sonnenburg, 2016. "Diet-induced extinctions in the gut microbiota compound over generations," Nature, Nature, vol. 529(7585), pages 212-215, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7585:d:10.1038_nature16504
    DOI: 10.1038/nature16504
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    Cited by:

    1. Huimin Ye & Sabrina Borusak & Claudia Eberl & Julia Krasenbrink & Anna S. Weiss & Song-Can Chen & Buck T. Hanson & Bela Hausmann & Craig W. Herbold & Manuel Pristner & Benjamin Zwirzitz & Benedikt War, 2023. "Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. M. C. Ramaboli & S. Ocvirk & M. Khan Mirzaei & B. L. Eberhart & M. Valdivia-Garcia & A. Metwaly & K. Neuhaus & G. Barker & J. Ru & L. T. Nesengani & D. Mahdi-Joest & A. S. Wilson & S. K. Joni & D. C. , 2024. "Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Alan C. Logan & Susan L. Prescott, 2017. "Astrofood, Priorities and Pandemics: Reflections of an Ultra-Processed Breakfast Program and Contemporary Dysbiotic Drift," Challenges, MDPI, vol. 8(2), pages 1-24, September.
    4. Giuliano Bonanomi & Mohamed Idbella & Ahmed M. Abd-ElGawad, 2021. "Microbiota Management for Effective Disease Suppression: A Systematic Comparison between Soil and Mammals Gut," Sustainability, MDPI, vol. 13(14), pages 1-16, July.
    5. Bo Tang & Li Tang & Shengpeng Li & Shuang Liu & Jialin He & Pan Li & Sumin Wang & Min Yang & Longhui Zhang & Yuanyuan Lei & Dianji Tu & Xuefeng Tang & Hua Hu & Qin Ouyang & Xia Chen & Shiming Yang, 2023. "Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Ren Dodge & Eric W. Jones & Haolong Zhu & Benjamin Obadia & Daniel J. Martinez & Chenhui Wang & Andrés Aranda-Díaz & Kevin Aumiller & Zhexian Liu & Marco Voltolini & Eoin L. Brodie & Kerwyn Casey Huan, 2023. "A symbiotic physical niche in Drosophila melanogaster regulates stable association of a multi-species gut microbiota," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    7. Sandra M. Holmberg & Rachel H. Feeney & Vishnu Prasoodanan P.K. & Fabiola Puértolas-Balint & Dhirendra K. Singh & Supapit Wongkuna & Lotte Zandbergen & Hans Hauner & Beate Brandl & Anni I. Nieminen & , 2024. "The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    8. Susan L. Prescott & Alan C. Logan, 2017. "Down to Earth: Planetary Health and Biophilosophy in the Symbiocene Epoch," Challenges, MDPI, vol. 8(2), pages 1-22, August.
    9. Karen D. Corbin & Elvis A. Carnero & Blake Dirks & Daria Igudesman & Fanchao Yi & Andrew Marcus & Taylor L. Davis & Richard E. Pratley & Bruce E. Rittmann & Rosa Krajmalnik-Brown & Steven R. Smith, 2023. "Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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