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Neutrophils support lung colonization of metastasis-initiating breast cancer cells

Author

Listed:
  • Stefanie K. Wculek

    (The Francis Crick Institute, Lincolns Inn Fields Laboratories)

  • Ilaria Malanchi

    (The Francis Crick Institute, Lincolns Inn Fields Laboratories)

Abstract

Neutrophils are shown to have a role in driving the metastasis of breast cancer cells to the lung, with neutrophil-derived leukotrienes promoting metastatic initiation in the lung by expanding the sub-pool of cancer cells with high tumorigenic potential.

Suggested Citation

  • Stefanie K. Wculek & Ilaria Malanchi, 2015. "Neutrophils support lung colonization of metastasis-initiating breast cancer cells," Nature, Nature, vol. 528(7582), pages 413-417, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7582:d:10.1038_nature16140
    DOI: 10.1038/nature16140
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    Cited by:

    1. Zhiyuan Zheng & Ya-nan Li & Shanfen Jia & Mengting Zhu & Lijuan Cao & Min Tao & Jingting Jiang & Shenghua Zhan & Yongjing Chen & Ping-Jin Gao & Weiguo Hu & Ying Wang & Changshun Shao & Yufang Shi, 2021. "Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Junho Lee & Donggu Lee & Sean Lawler & Yangjin Kim, 2021. "Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural insights from a computational model," PLOS Computational Biology, Public Library of Science, vol. 17(2), pages 1-29, February.
    3. Ariane F. Busso-Lopes & Leandro X. Neves & Guilherme A. Câmara & Daniela C. Granato & Marco Antônio M. Pretti & Henry Heberle & Fábio M. S. Patroni & Jamile Sá & Sami Yokoo & César Rivera & Romênia R., 2022. "Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    4. Qiaoqi Sui & Xi Zhang & Chao Chen & Jinghua Tang & Jiehai Yu & Weihao Li & Kai Han & Wu Jiang & Leen Liao & Lingheng Kong & Yuan Li & Zhenlin Hou & Chi Zhou & Chenzhi Zhang & Linjie Zhang & Binyi Xiao, 2022. "Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Shu Zhang & Wen Fang & Siqi Zhou & Dongming Zhu & Ruidong Chen & Xin Gao & Zhuojin Li & Yao Fu & Yixuan Zhang & Fa Yang & Jing Zhao & Hao Wu & Pin Wang & Yonghua Shen & Shanshan Shen & Guifang Xu & Le, 2023. "Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Charlotte R. Bell & Victoria S. Pelly & Agrin Moeini & Shih-Chieh Chiang & Eimear Flanagan & Christian P. Bromley & Christopher Clark & Charles H. Earnshaw & Maria A. Koufaki & Eduardo Bonavita & Sant, 2022. "Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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