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Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract

Author

Listed:
  • Sushma Kommineni

    (Medical College of Wisconsin
    Medical College of Wisconsin)

  • Daniel J. Bretl

    (Medical College of Wisconsin)

  • Vy Lam

    (Medical College of Wisconsin)

  • Rajrupa Chakraborty

    (Medical College of Wisconsin
    Medical College of Wisconsin)

  • Michael Hayward

    (Medical College of Wisconsin)

  • Pippa Simpson

    (Medical College of Wisconsin)

  • Yumei Cao

    (Medical College of Wisconsin)

  • Pavlos Bousounis

    (Medical College of Wisconsin)

  • Christopher J. Kristich

    (Medical College of Wisconsin)

  • Nita H. Salzman

    (Medical College of Wisconsin
    Medical College of Wisconsin)

Abstract

The authors develop a mouse model of Enterococcus faecalis colonization to show that enterococci harbouring the bacteriocin-expressing plasmid pPD1 replace indigenous enterococci and have the ability to transfer the plasmid to other enterococci, which enhances the stability of the bacteriocin-expressing bacteria in the gut; this result suggests a therapeutic approach that leverages niche-specificity to eliminate antibiotic-resistant bacteria from infected individuals.

Suggested Citation

  • Sushma Kommineni & Daniel J. Bretl & Vy Lam & Rajrupa Chakraborty & Michael Hayward & Pippa Simpson & Yumei Cao & Pavlos Bousounis & Christopher J. Kristich & Nita H. Salzman, 2015. "Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract," Nature, Nature, vol. 526(7575), pages 719-722, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7575:d:10.1038_nature15524
    DOI: 10.1038/nature15524
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    Cited by:

    1. Elsa Hansen & Jason Karslake & Robert J Woods & Andrew F Read & Kevin B Wood, 2020. "Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations," PLOS Biology, Public Library of Science, vol. 18(5), pages 1-20, May.
    2. Sandrine Isaac & Alejandra Flor-Duro & Gloria Carruana & Leonor Puchades-Carrasco & Anna Quirant & Marina Lopez-Nogueroles & Antonio Pineda-Lucena & Marc Garcia-Garcera & Carles Ubeda, 2022. "Microbiome-mediated fructose depletion restricts murine gut colonization by vancomycin-resistant Enterococcus," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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