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Patient-centric trials for therapeutic development in precision oncology

Author

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  • Andrew V. Biankin

    (Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
    The Kinghorn Cancer Centre, Garvan Institute of Medical Research
    Bankstown Hospital
    South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales)

  • Steven Piantadosi

    (Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center)

  • Simon J. Hollingsworth

    (Innovative Medicines & Early Development Oncology, AstraZeneca, Cambridge Science Park)

Abstract

An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours. Considerable associated challenges include how to advance and implement targeted drug-development strategies. Precision medicine centres on delivering the most appropriate therapy to a patient on the basis of clinical and molecular features of their disease. The development of therapeutic agents that target molecular mechanisms is driving innovation in clinical-trial strategies. Although progress has been made, modifications to existing core paradigms in oncology drug development will be required to realize fully the promise of precision medicine.

Suggested Citation

  • Andrew V. Biankin & Steven Piantadosi & Simon J. Hollingsworth, 2015. "Patient-centric trials for therapeutic development in precision oncology," Nature, Nature, vol. 526(7573), pages 361-370, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7573:d:10.1038_nature15819
    DOI: 10.1038/nature15819
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    Cited by:

    1. Nicole Bijlsma & Marc M. Cohen, 2016. "Environmental Chemical Assessment in Clinical Practice: Unveiling the Elephant in the Room," IJERPH, MDPI, vol. 13(2), pages 1-27, February.
    2. Olivia Kim-McManus & Joseph G. Gleeson & Laurence Mignon & Amena Smith Fine & Winston Yan & Nicole Nolen & Scott Demarest & Elizabeth Berry-Kravis & Richard Finkel & Stefanie Leonard & Samuel Finlayso, 2024. "A framework for N-of-1 trials of individualized gene-targeted therapies for genetic diseases," Nature Communications, Nature, vol. 15(1), pages 1-5, December.
    3. Rong A & Haoyu Wang & Chaoqun Nie & Zhaoguo Han & Meifang Zhou & Olagbaju Oluwatosin Atinuke & Kaiqi Wang & Xiance Wang & Shuang Liu & Jingshi Zhao & Wenju Qiao & Xiaohong Sun & Lina Wu & Xilin Sun, 2023. "Glycerol-weighted chemical exchange saturation transfer nanoprobes allow 19F/1H dual-modality magnetic resonance imaging-guided cancer radiotherapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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