Author
Listed:
- Rong A
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Haoyu Wang
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Chaoqun Nie
(Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Zhaoguo Han
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Meifang Zhou
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Olagbaju Oluwatosin Atinuke
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Kaiqi Wang
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Xiance Wang
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Shuang Liu
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Jingshi Zhao
(Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Wenju Qiao
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Xiaohong Sun
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Lina Wu
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
- Xilin Sun
(the Fourth Hospital of Harbin Medical University
Molecular Imaging Research Center (MIRC) of Harbin Medical University)
Abstract
Recently, radiotherapy (RT) has entered a new realm of precision cancer therapy with the introduction of magnetic resonance (MR) imaging guided radiotherapy systems into the clinic. Nonetheless, identifying an optimized radiotherapy time window (ORTW) is still critical for the best therapeutic efficacy of RT. Here we describe pH and O2 dual-sensitive, perfluorooctylbromide (PFOB)-based and glycerol-weighted chemical exchange saturation transfer (CEST) nano-molecular imaging probes (Gly-PFOBs) with dual fluorine and hydrogen proton based CEST MR imaging properties (19F/1H-CEST). Oxygenated Gly-PFOBs ameliorate tumor hypoxia and improve O2-dependent radiotherapy. Moreover, the pH and O2 dual-sensitive properties of Gly-PFOBs could be quantitatively, spatially, and temporally monitored by 19F/1H-CEST imaging to optimize ORTW. In this study, we describe the CEST signal characteristics exhibited by the glycerol components of Gly-PFOBs. The pH and O2 dual-sensitive Gly-PFOBs with19F/1H-CEST MR dual-modality imaging properties, with superior therapeutic efficacy and biosafety, are employed for sensitive imaging-guided lung cancer RT, illustrating the potential of multi-functional imaging to noninvasively monitor and enhance RT-integrated effectiveness.
Suggested Citation
Rong A & Haoyu Wang & Chaoqun Nie & Zhaoguo Han & Meifang Zhou & Olagbaju Oluwatosin Atinuke & Kaiqi Wang & Xiance Wang & Shuang Liu & Jingshi Zhao & Wenju Qiao & Xiaohong Sun & Lina Wu & Xilin Sun, 2023.
"Glycerol-weighted chemical exchange saturation transfer nanoprobes allow 19F/1H dual-modality magnetic resonance imaging-guided cancer radiotherapy,"
Nature Communications, Nature, vol. 14(1), pages 1-17, December.
Handle:
RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42286-3
DOI: 10.1038/s41467-023-42286-3
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