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The soft palate is an important site of adaptation for transmissible influenza viruses

Author

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  • Seema S. Lakdawala

    (Laboratory of infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
    †Present addresses: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15217, USA (S.S.L.); National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, 26505 USA (M.O.); Virology Surveillance and Diagnosis Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA (D.E.W.).)

  • Akila Jayaraman

    (Koch Institute for Integrative Cancer Research, Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology)

  • Rebecca A. Halpin

    (J. Craig Venter Institute)

  • Elaine W. Lamirande

    (Laboratory of infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Angela R. Shih

    (Laboratory of infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Timothy B. Stockwell

    (J. Craig Venter Institute)

  • Xudong Lin

    (J. Craig Venter Institute)

  • Ari Simenauer

    (J. Craig Venter Institute)

  • Christopher T. Hanson

    (Laboratory of infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Leatrice Vogel

    (Laboratory of infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Myeisha Paskel

    (Laboratory of infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Mahnaz Minai

    (Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Ian Moore

    (Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Marlene Orandle

    (Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
    †Present addresses: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15217, USA (S.S.L.); National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, 26505 USA (M.O.); Virology Surveillance and Diagnosis Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA (D.E.W.).)

  • Suman R. Das

    (J. Craig Venter Institute)

  • David E. Wentworth

    (J. Craig Venter Institute
    †Present addresses: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15217, USA (S.S.L.); National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, 26505 USA (M.O.); Virology Surveillance and Diagnosis Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA (D.E.W.).)

  • Ram Sasisekharan

    (Koch Institute for Integrative Cancer Research, Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology)

  • Kanta Subbarao

    (Laboratory of infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

Efficient airborne transmission of influenza viruses between humans is associated with use of α2,6-linked sialic acids, not α2,3-linked sialic acids; however, using a loss-of-function approach in which a 2009 pandemic H1N1 influenza virus was engineered to bind α2,3 sialic acids, this study shows in ferrets that the soft palate is an important site for the switch of receptor usage to take place, and reveals that this tissue rapidly selects for transmissible influenza virus with human receptor preference.

Suggested Citation

  • Seema S. Lakdawala & Akila Jayaraman & Rebecca A. Halpin & Elaine W. Lamirande & Angela R. Shih & Timothy B. Stockwell & Xudong Lin & Ari Simenauer & Christopher T. Hanson & Leatrice Vogel & Myeisha P, 2015. "The soft palate is an important site of adaptation for transmissible influenza viruses," Nature, Nature, vol. 526(7571), pages 122-125, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7571:d:10.1038_nature15379
    DOI: 10.1038/nature15379
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    Cited by:

    1. Katherine A. Amato & Luis A. Haddock & Katarina M. Braun & Victoria Meliopoulos & Brandi Livingston & Rebekah Honce & Grace A. Schaack & Emma Boehm & Christina A. Higgins & Gabrielle L. Barry & Katia , 2022. "Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ketaki Ganti & Anish Bagga & Silvia Carnaccini & Lucas M. Ferreri & Ginger Geiger & C. Joaquin Caceres & Brittany Seibert & Yonghai Li & Liping Wang & Taeyong Kwon & Yuhao Li & Igor Morozov & Wenjun M, 2022. "Influenza A virus reassortment in mammals gives rise to genetically distinct within-host subpopulations," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Valerie Le Sage & Nicole C. Rockey & Andrea J. French & Ryan McBride & Kevin R. McCarthy & Lora H. Rigatti & Meredith J. Shephard & Jennifer E. Jones & Sydney G. Walter & Joshua D. Doyle & Lingqing Xu, 2024. "Potential pandemic risk of circulating swine H1N2 influenza viruses," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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